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SIGIRR — TLR4
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Qin et al., J Biol Chem 2005
:
SIGIRR inhibits interleukin-1 receptor- and
toll-like receptor 4-mediated signaling through different mechanisms
Huang et al., J Immunol 2006
(Keratitis...) :
These data provide evidence that
SIGIRR is critical in resistance to P. aeruginosa corneal infection by down regulating type 1 immunity, and that it negatively
regulates IL-1 and
TLR4 signaling
Lech et al., Kidney Int 2007
:
The lack of
TIR8/SIGIRR does not
enhance TLR/IL-1R signaling in tubular epithelial cells as was observed in monocytes ...
TIR8/SIGIRR does not
suppress TLR signaling in tubular epithelial cells, which supports their role as sensors of microbial infection in the kidney
Noris et al., J Immunol 2009
(Acute Disease...) :
In this study, we tested the hypothesis that
Toll-IL-1R8 (TIR8) , a negative
regulator of
TLR/IL-1R highly expressed in the kidney, modulates immune cell activation underlying kidney rejection
Lech et al., J Pathol 2010
(Genetic Predisposition to Disease...) :
Hence, we hypothesized that
TIR8/SIGIRR , an endogenous
TLR inhibitor , prevents oil induced SLE
Khan et al., J Immunol 2010
:
In this study, we investigated the
role of
Sigirr in regulating epithelial-specific
TLR responses and characterized its expression in colonic biopsy specimens
Zhang et al., Mol Biol Rep 2011
:
SIGIRR inhibits
toll-like receptor 4 , 5, 9-mediated immune responses in human airway epithelial cells ... In conclusion,
SIGIRR can
inhibit TLR4 , 5, and 9-mediated immune responses in HAEC and may be a valuable therapeutic target for the prevention of ALI/ARDS
Villena et al., Clinical and vaccine immunology : CVI 2012
:
Our results also indicated that TLR2 has an important role in the anti-inflammatory activity of L. jensenii TL2937, since anti-TLR2 antibodies blocked the upregulation of
SIGIRR and IRAK-M in CD172a ( + ) APCs and the production of IL-10 in
response to
TLR4 activation
Barry et al., Am J Respir Cell Mol Biol 2013
(Respiratory Hypersensitivity) :
Here we sought to determine whether the absence of
Toll-interleukin-1 receptor (TIR)-8 , a negative
regulator of
TLR4 signaling that is highly expressed in airway epithelial cells, would exacerbate HDM induced asthma in a murine model
Sham et al., PLoS Pathog 2013
:
One reason for the innate hypo-responsiveness of IEC is their expression of
Single Ig IL-1 Related Receptor (SIGIRR) , a negative
regulator of interleukin (IL)-1 and
TLR signaling