◀ Back to TLR4
TLR3 — TLR4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
TLR3
→
TLR4
(reaction)
Kishimoto et al., J Biol Chem 2000, Kalai et al., Cell Death Differ 2002, Donepudi et al., Mol Cell 2003, Fitzgerald et al., Nat Immunol 2003, Mori et al., J Biol Chem 2004, Kaiser et al., J Immunol 2005, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Adhikari et al., Oncogene 2007, Panne et al., J Biol Chem 2007, Keller et al., Structure 2009, Oberst et al., J Biol Chem 2010, Feoktistova et al., Mol Cell 2011, Estornes et al., Cell Death Differ 2012
Text-mined interactions from Literome
Zhang et al., FEBS Lett 2002
:
Co-expression of the alphav-TLR and beta5-TLR chimeras in 293T cells generated 10
TLR homodimers, but only
TLR4/4 could effectively
activate NF-kappaB
Harii et al., Mol Endocrinol 2005
(Thyroiditis, Autoimmune...) :
We conclude that functional TLR3 are present on thyrocytes
; TLR3 downstream signals can be overexpressed by pathogen related stimuli ; overexpression can be reversed by phenylmethimazole to a significantly greater extent than MMI by inhibiting only the IFN regulatory factor-3/IFN-beta/signal transducers and activation of transcription arm of the TLR3 signal system ; and
TLR3 overexpression can
induce an innate immune response in thyrocytes, which may be important in the pathogenesis of Hashimoto 's thyroiditis and in the immune cell infiltrates
Cabral et al., J Infect Dis 2006
:
TLR4 stimulation
had no effect on TLR2,
TLR1 , and TLR5 expression
Mueller et al., J Immunol 2006
:
TLR4/MD-2 mediated LPS uptake and
TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Asakura et al., Am J Hematol 2007
:
Serine/threonine kinase PKR : a sentinel kinase that discriminates a signaling pathway
mediated by
TLR4 from those mediated by
TLR3 and TLR9
Sel et al., J Immunol 2007
(Asthma...) :
These data indicate that
TLR-3 or TLR-7
activation by viral
TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10
McCoy et al., J Biol Chem 2008
:
IRF3 can be
activated by
Toll-like receptor 3 (TLR3) in response to the double stranded RNA mimic poly ( I-C ) and by
TLR4 in response to lipopolysaccharide (LPS)
Furuta et al., Eur J Immunol 2008
(Malaria) :
Innate immune responses to PbAPrx were examined using cells from mice deficient in Toll-like receptors ( TLR ) or related molecules, and it was demonstrated that responses were severely impaired in
TLR4 ( -/- ), MyD88 ( -/- ) and MD-2 ( -/- ) mice, but not in Toll/IL-1 receptor domain containing adaptor
inducing IFN-gamma ( TRIF ) ( -/- ),
TLR2 ( -/- ) or radioprotective 105 ( RP105 ) ( -/- ) mice
Kimman et al., PloS one 2008
:
Activation of the
Toll-like receptor ( TLR ) signaling pathway through
TLR4 may be important in the induction of protective immunity against Bordetella pertussis with TLR4 mediated activation of dendritic and B cells, induction of cytokine expression, and reversal of tolerance as crucial steps
Regueiro et al., Infect Immun 2009
:
We showed that Klebsiella induced TLR2 and
TLR4 upregulation was
dependent on
TLR activation
Messlik et al., J Proteome Res 2009
(Chronic Disease...) :
The aim of this study was to characterize the
role of TLR2 or
TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and
TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
van Bruggen et al., J Innate Immun 2010
(Bacterial Infections...) :
Surprisingly, the reactivity towards certain established TLR ligands, imiquimod and ODN-CpG, was unaffected by IRAK-4 deficiency, demonstrating their activity is independent of
TLR. TLR-4 dependent signaling in neutrophils was totally dependent on IRAK-4 without any major TRIF mediated contribution
Yang et al., J Exp Clin Cancer Res 2010
(Breast Neoplasms) :
TLR4AsiRNA,
TLR4BsiRNA and TLR4CsiRNA were found to significantly
inhibit TLR4 expression in MDA-MB-231 at both mRNA and protein levels as compared to vector control ( vector transfected cells )
Jones et al., J Immunol 2010
:
Of particular significance was that progesterone was able to significantly inhibit
TLR3- but not
TLR4 induced CD40 expression in bone marrow derived DCs
Song et al., Leukemia 2011
:
LBH589 also significantly repressed the production of interleukin (IL)-6, IL-10, IL-12p70, IL-23 and tumor necrosis factor-a by
Toll-like receptor (TLR)3 and
TLR4 induced DC
activation , indicating an important role of HDAC activity in immune regulation and inflammation
Kim et al., FEMS Microbiol Lett 2012
(Inflammation) :
L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2,
TLR4 , and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative
regulator of
TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011
:
CD14,
TLR4 receptors are involved in P.e-LPS effect and CD14,
TLR2 and TLR4 receptors are
involved in P.g-LPS effect in mouse osteoblast
Raicevic et al., Tissue Eng Part A 2012
:
Inflammation was mimicked by a cytokine cocktail, and
TLR activation was
induced through
TLR3 and TLR4 ligation ... Inflammation was mimicked by a cytokine cocktail, and
TLR activation was
induced through TLR3 and
TLR4 ligation
Neal et al., J Biol Chem 2012
(Enterocolitis, Necrotizing) :
To define molecular mechanisms involved,
TLR4 inhibited ISC proliferation and increased apoptosis via the p53-up regulated modulator of apoptosis ( PUMA ), as
TLR4 did not
affect crypt proliferation or apoptosis in organoids or mice lacking PUMA
Deng et al., Immunol Cell Biol 2013
:
The
TLR signals that regulate the phagocytic ability of macrophages were also
induced by
TLR4 and TLR5 activation
Melkamu et al., Journal of cell communication and signaling 2013
:
These findings demonstrate that
TLR3 activation differentially
regulates TLR expression through autocrine signaling involving IL-6 secretion, IL-6Ra activation and subsequent phosphorylation of Stat3