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DKK1 — TP53

Text-mined interactions from Literome

Wang et al., Oncogene 2000 : Dickkopf-1 , an inhibitor of the Wnt signaling pathway, is induced by p53 ... In this study, we found that Dkk-1 is induced by wild-type p53 but not mutant p53 ( R249S ) ... We found that Dkk-1 has no effect on proliferation of cells that are not transformed by Wnt. Taken together, these results suggest that Dkk-1 may mediate p53 tumor suppression by antagonizing the Wnt signaling pathway
Caricasole et al., J Neurosci 2004 (Alzheimer Disease...) : DKK1 was induced at late times after betaAP exposure, and its expression was dependent on the tumor suppressing protein p53
Colla et al., Blood 2007 (Multiple Myeloma) : Despite its role as a tumor suppressor and mediator of apoptosis in other cell types including osteoblasts, our data suggest that DKK1 , a stress-responsive gene in MM, does not mediate apoptotic signaling, is not activated by TP53 , and its forced overexpression could not inhibit cell growth or sensitize MM cells to apoptosis following treatment with thalidomide or lenalidomide
Fujita et al., Molecular cancer 2007 (Plasmacytoma) : We found that Dkk1 and -2 restored the Wnt3a dependent reduction of alkaline phosphatase (ALP), Osterix and p53 , indicating that mitigated Wnt/beta-catenin signaling promotes certain aspects of early osteoblastogenesis through the BMP-p53-Osterix-ALP axis