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IGF2 — TP53

Text-mined interactions from Literome

Lee et al., Oncogene 2000 (Carcinoma, Hepatocellular...) : Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes ; implications for a gain-of-function during the formation of hepatocellular carcinoma ... p53mt249 markedly increases insulin-like growth factor II (IGF-II) transcription largely from promoter 4, accumulating the fetal form of IGF-II
Girnita et al., Cancer Res 2000 (Melanoma) : Taken together, our results suggest that up-regulation of IGF-IR as a result of expression of aberrant p53 may be important for the growth and survival of malignant cells
Idelman et al., J Biol Chem 2003 (Bone Neoplasms...) : WT1 splice variants lacking a KTS insert between zinc fingers 3 and 4 suppressed IGF-IR promoter activity in the absence of p53 or in the presence of wild-type p53 ... In the presence of mutant p53 , WT1 can not repress the IGF-IR promoter
Lee et al., Mol Cell Endocrinol 2003 (Carcinoma, Hepatocellular) : Activation of insulin-like growth factor II signaling by mutant type p53 : physiological implications for potentiation of IGF-II signaling by p53 mutant 249 ... p53mt249 increased the number of IGF-II binding sites with no change in the affinity of IGF-IR
Harms et al., Mol Cell Biol 2005 : Through the use of engineered deletion mutants, we found that activation domain 2 is required for induction of the proapoptotic target gene insulin-like growth factor binding protein 3 ( IGFBP3 ) by p53 and that the basic domain inhibits induction of this gene by p53
Ma et al., J Exp Clin Cancer Res 2006 (Adenocarcinoma...) : It was also found that the absence of mutant p53 affected the signal transduction of TGFbeta/BMP pathway mainly by up-regulating the expression of BMP superfamily cytokine growth differentiation factor 9 (GDF9), activin superfamily cytokine inhibin beta B (INHBB), smads target genes insulin-like growth factor binding protein 3 ( IGFBP3 ) and involucrin (IVL)
Adamson et al., Altern Lab Anim 2007 : Under these conditions, IGF-1 may increase p53 expression to restrain abnormal cell proliferation
Scrable et al., Exp Gerontol 2009 (Starvation) : Running on empty : how p53 controls INS/IGF signaling and affects life span
Kuramoto et al., Acta Med Okayama 2008 (Cervical Intraepithelial Neoplasia...) : It is postulated that a decrease of p53 protein levels due to human papillomavirus ( HPV ) infection may contribute to the up-regulation of IGF-IR expression in cervical cancer cells because transcription of IGF-IR is strictly down-regulated by p53
Attias-Geva et al., Eur J Cancer 2012 (Cystadenocarcinoma, Serous...) : In addition, using USC derived cell lines we provide evidence that p53 regulates IGF-IR gene expression via a mechanism that involves repression of the IGF-IR promoter ... In summary, we provide evidence that p53 regulates IGF-IR gene expression in USC cells via a mechanism that involves repression of the IGF-IR promoter
Zhang et al., Cancer Res 1996 (Leiomyosarcoma...) : To investigate whether p53 regulates IGF-II gene expression, we transfected wild-type p53 expression vectors and luciferase constructs driven by IGF-II P3 promotors into multiple cell lines ... We found that p53 reduced , in a dose dependent manner, both endogenous IGF-II P3 transcripts and transfected P3 luciferase expression ... Our results suggest that p53 may play a role in regulation of IGF-II gene expression
Ohlsson et al., Endocrinology 1998 (Osteosarcoma) : The aim of the present study was to investigate whether the IGF-IR is a physiological target for p53 in osteosarcoma cells ... The p53 induced regulation of IGF-IR levels was studied in a tetracycline regulated expression system ... When expressed in Saos-2, osteosarcoma cells that lack p53, wild-type p53 decreased, whereas mutated p53 increased IGF-IR expression, and IGF-I induced tyrosine phosphorylation of the IGF-IR ... However, Sp1 counteracted the inhibitory effect of p53 on IGF-IR promoter activity in a dose dependent manner ... In conclusion, p53 regulates IGF-IR expression, as reflected by a reduction in IGF-IR protein and a parallel reduction in IGF-I induced tyrosine phosphorylation of the IGF-IR and IRS-1 in an osteosarcoma cell line
Cianfarani et al., Eur J Clin Invest 1998 (Chromosome Fragility) : IGF-I and -II also stimulate p53 protein expression that, taking part in DNA repair, may counteract the IGF action on genome stability
Zhang et al., DNA Cell Biol 1998 (Rhabdomyosarcoma) : p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells ... We have previously shown that p53 inhibits IGFII P3 promoter activity and decreases endogenous IGFII gene expression derived from the P3 promoter in rhabdomyosarcomas by interfering with TBP binding to the TATA element of the IGFII P3 promoter ... In this report, we demonstrate that wild-type p53 expression in rhabdomyosarcoma cell lines containing mutant p53 leads to a decrease in the activity of another active IGFII promoter, P4, and a 5-fold reduction of IGFII mRNA derived from the P4 promoter ... Our results suggest that p53 inhibits IGFII P4 promoter activity by a mechanism different than its effect on the P3 promoter