◀ Back to STAT3
BCL2L1 — STAT3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
BCL2L1
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STAT3
(increases, BCL2L1 Activity)
Evidence: To explore this further, we have blocked endogenous ErbB3 transcription, thereby engineering tumor cells with overexpressed, fully active ErbB2 but lacking ErbB3 (T. Holbro and N.E. Hynes, unpublished data). As a consequence, these cells have decreased PI-3K/PKB signaling, a reduction in D-type cyclin levels, and show an increase in the G1 phase of the cell cycle. A main effector of ErbB signaling, the PI-3K/PKB pathway, is particularly important in mediating cell survival 103 T. Holbro et al. /...
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NCI Pathway Database IL6-mediated signaling events:
STAT3 (dimer ) complex (STAT3)
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BCL-X(L) (BCL2L1)
(transcription, activates)
Catlett-Falcone et al., Immunity 1999*
Evidence: mutant phenotype, reporter gene
Text-mined interactions from Literome
Beales et al., J Mol Endocrinol 2009
(Adenocarcinoma...) :
Novel small molecule inhibitors of JAK2 and
STAT3 as well as STAT3 siRNA blocked the anti-apoptotic effects of G-Gly and
inhibited the induction of survivin and
BCL2L1 in OE33 cells
Adach-Kilon et al., J Cell Biochem 2011
(Brain Neoplasms...) :
In this study, we employed DNA decoys, siRNAs, and protein overexpression, to elucidate the
role of Stat1 and
Stat3 in regulation of expression of endogenous Stat3-target genes (
Bcl2l1 , Myc, Ccnd1 ) and a Stat-driven reporter plasmid, in rat C6 glioma cells