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EGFR — GRP

Text-mined interactions from Literome

Lui et al., Oncogene 2003 (Carcinoma, Squamous Cell...) : Mitogenic effects of gastrin releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor ... In HNSCC cells that express elevated levels of both GRPR and EGFR, we found that GRP induced rapid phosphorylation of EGFR as well as p44/42-MAPK activation
Zhang et al., Cancer Res 2004 (Carcinoma, Squamous Cell...) : GRP can induce rapid phosphorylation of EGFR and p42/44 mitogen activated protein kinase ( MAPK ) activation in part via extracellular release of transforming growth factor alpha ( TGF-alpha ) by matrix metalloproteinases ( MMPs ) ... To further elucidate the mechanism of activation of EGFR by GRP in HNSCC, we investigated the role of Src family kinases ... Blockade of Src family kinases using an Src-specific tyrosine kinase inhibitor A-419259 decreased GRP induced EGFR phosphorylation and MAPK activation
Thomas et al., Neoplasia (New York, N.Y.) 2005 (Carcinoma, Non-Small-Cell Lung...) : GRP induced rapid activation of p44/42 MAPK in lung cancer cells through EGFR ... EGF and GRP both stimulated NSCLC proliferation, and inhibition of either EGFR or GRPR resulted in cell death
Liu et al., Exp Cell Res 2007 (Carcinoma, Non-Small-Cell Lung...) : Transfection of dominant negative c-Src abolished GRP induced EGFR and Akt activation
Moody et al., Peptides 2011 (Lung Neoplasms) : Similarly, ( DTyr ( 6 ), R-Apa ( 11 ), Phe ( 13 ), Nle ( 14 ) ) bombesin ( 6-14 ) ( BA2 ) and ( DTyr ( 6 ), R-Apa ( 11 ), 4-Cl, Phe ( 13 ), Nle ( 14 ) ) bombesin ( 6-14 ) ( BA3 ) but not gastrin releasing peptide (GRP) or neuromedin B (NMB) caused EGFR transactivation in NCI-H1299-BRS-3 cells