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HIF1A — KDR
Text-mined interactions from Literome
Calvani et al., Cancer Res 2008
(Colonic Neoplasms) :
Inhibition of VEGF or VEGF receptor 2
(VEGFR2)/KDR , but not VEGFR1/Flt-1, was
sufficient to abrogate VEGF mediated induction of
HIF-1 alpha and survival in sensitive HCT116, but not in resistant HT29, colon cancer cells
Choi et al., PloS one 2008
(Anoxia...) :
This blunted pro-angiogenic response to hypoxia in the hypertrophied myocardium was associated with lower HIF-2alpha and
VEGFR-2 levels and
increased HIF-1alpha activity and VEGFR-1 expression
Spirli et al., Gastroenterology 2010
(Cysts...) :
In Pkd2-defective LCECs, PKA dependent ERK1/2 signaling controls
HIF-1alpha dependent VEGF secretion and
VEGFR-2 signaling
DU et al., Zhong Xi Yi Jie He Xue Bao 2010
(Myocardial Infarction...) :
After 12-day treatment, microvessel density (MVD) in ischemic myocardium was detected by immunohistochemical method, while expressions of
VEGFR-2 and HIF-1alpha proteins were detected by Western blotting, and expressions of VEGFR-2 and
HIF-1alpha mRNAs were
detected by real-time fluorescent quantitative polymerase chain reaction