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IFI27 — PDGFB
Text-mined interactions from Literome
Zhan et al., Arterioscler Thromb Vasc Biol 2002
:
Ad-DN-c-Jun attenuated PDGF-BB induced downregulation of p27 ( Kip1 ), as shown by Western blot analysis, and the prevented
PDGF-BB induced decrease in cyclin E/cyclin dependent kinase 2 complex associated
p27 ( Kip1 ), as shown by immunoprecipitation study
Sakakibara et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
PDGF-BB regulates
p27 expression through ERK dependent RNA turn-over in vascular smooth muscle cells ... In summary, our data suggest that
p27 is
down-regulated by
PDGF-BB in vascular smooth muscle cells through an ERK dependent posttranscriptional mechanism
Abid et al., J Biol Chem 2005
(Hyperplasia) :
PDGF-BB, tumor necrosis factor-alpha, and insulin-like growth factor 1 treatment resulted in the nuclear exclusion of FoxO, whereas
PDGF-BB alone
down-regulated the FoxO target gene,
p27 ( kip1 ), and enhanced cell survival and progression through the cell cycle
Xu et al., Clin Exp Pharmacol Physiol 2011
:
In addition, TSG suppressed
PDGF-BB induced downregulation of
p27 and upregulation of p21, as well as PDGF-BB induced activation of ERK1/2