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IL10 — IL2RA

Text-mined interactions from Literome

Suri-Payer et al., J Autoimmun 2001 (Autoimmune Diseases...) : CD4 ( + ) CD25 ( + ) cells also protected RAG-2 ( -/- ) recipients from colitis and inhibitory activity was partially dependent on IL-10 expression
Dieckmann et al., J Exp Med 2002 : Human CD4 ( + ) CD25 ( + ) regulatory, contact dependent T cells induce interleukin 10-producing , contact independent type 1-like regulatory T cells [ corrected ] ... Here we show that human CD4 ( + ) CD25 ( + ) T cells induce long lasting anergy and production of interleukin (IL)-10 in CD4 ( + ) CD25 ( - ) T cells
Bellinghausen et al., J Allergy Clin Immunol 2003 (Hypersensitivity) : CD4 ( + ) CD25 ( + ) T cells from the nonatopic donors and from the majority of the patients investigated proliferated poorly, produced fewer cytokines, and inhibited the proliferation and T ( H ) 1 ( IFN-gamma ) and T ( H ) 2 ( IL-4 and IL-5 ) cytokine production of CD4 ( + ) CD25 ( - ) T cells but not IL-10 production
Asseman et al., J Immunol 2003 (Colitis) : Interestingly, IL-10 was not absolutely required for CD4 ( + ) CD25 ( + ) T cell mediated inhibition of colitis induced by transfer of naive CD4 ( + ) CD45RB ( high ) cells, suggesting a differential requirement for IL-10 in the regulation of naive and Ag-experienced T cells
Horwitz et al., J Leukoc Biol 2003 : The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets
Erdman et al., Cancer Res 2003 (Adenocarcinoma...) : CD4 ( + ) CD25 ( + ) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice
Zheng et al., J Immunol 2004 : The suppressive effects of these secondary CD4 ( + ) CD25 ( + ) cells depend upon TGF-beta and IL-10
Tchórzewski et al., Med Sci Monit 2005 (Autoimmune Diseases...) : We analyzed reactive oxygen intermediate ( ROI ) production by peripheral blood granulocytes, the production of IL-2, IL-5, IL-10 , IL-12, and TNF-alpha cytokines by lymphocytes, and the activation of CD25 , CD26, CD69, CD71, and HLA DR antigen expression
Baecher-Allan et al., J Immunol 2006 : In striking contrast, MHC-II- CD4+ CD25 ( high ) Treg induce early IL-4 and IL-10 secretion and a late Foxp3 associated contact dependent suppression
Larmonier et al., Cancer Immunol Immunother 2007 (Leukemia) : Tumor derived CD4 ( + ) CD25 ( + ) regulatory T cell suppression of dendritic cell function involves TGF-beta and IL-10
Caudy et al., J Allergy Clin Immunol 2007 (Genetic Diseases, X-Linked...) : CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes
Charerntantanakul et al., Viral Immunol 2006 (Porcine Reproductive and Respiratory Syndrome) : Increased IL-10 gene expression contributed to significantly reduced % IFN-gamma ( + ) and % TNF-alpha ( + ), but not % CD25 ( + ), as determined by IL-10 neutralization assay
Agnholt et al., Scand J Immunol 2007 (Crohn Disease) : OPN increased CD69 and CD25 expression and enhanced T-cell IFN-gamma and TNF-alpha production in a dose dependent fashion with higher levels in CD than in healthy controls ( HC ), but induced a concomitant higher IL-10 production in HC than CD
Liu et al., Zhonghua Yi Xue Za Zhi 2007 : ( 1 ) The expression of CD25 is suppressed in a dose dependent manner when the T-lymphocytes are co-cultured with 10,000 MSCs or more, while 100 MSCs have no detectable effect ; ( 2 ) The suppression of CD25 can be lasted more than 96 hrs ; ( 3 ) The down regulation of CD25 is mediated by some soluble factors ; ( 4 ) The reduced expression of CD25 caused by MSC inhibition is not mediated by TGF-beta1 and IL-10
Li et al., J Neuroimmunol 2008 (Genetic Predisposition to Disease...) : EAMG resistance was associated with reduced lymph node cell IL-6 and IL-10 production and increased CD4 ( + ) CD25 ( + ) cell ratios in lymph nodes
Zhao et al., Leukemia 2008 (Hypersensitivity, Delayed) : sorafenib also caused G ( 0 ) /G ( 1 ) phase arrest, inhibition of CD25 and CD69 expression, interleukin-2 production and LCK phosphorylation in the T cells ; all of these effects exhibited dose and time dependence
Hahn et al., Immunol Lett 2008 (Respiratory Hypersensitivity) : These cells also reduce IL-10 levels in the airways, suggesting that they might function by inhibiting CD4 ( + ) CD25 ( + ) regulatory T cells ( T ( reg ) ) or other CD4 ( + ) T cells capable of producing IL-10 and suppressing AHR
Chaput et al., Gut 2009 (Adenocarcinoma...) : Finally, interleukin 6 and TGF beta 1 synergistically induced the generation of CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Silva-Campa et al., Virology 2009 (Porcine Reproductive and Respiratory Syndrome) : Analysis of the expressed cytokines suggested that the induction of Foxp3 ( + ) CD25 ( + ) T cells is dependent on TGF-beta but not IL-10
Fu et al., Cell Immunol 2010 (Hypersensitivity) : Our findings confirm that smDCs constitute an independent subgroup of DCs that play a key role for inducing CD4 ( + ) CD25 ( + ) Treg cells to express high IL-10 levels, which induce hyporesponsiveness of effector T cells
Zhou et al., Clin Dev Immunol 2010 : These results suggested that lactadherin could adjust intestinal DCs activity, induce CD3 ( + ) CD4 ( + ) CD25 ( + ) T cell differentiation, and enhance IL-10 production
Liu et al., J Immunol 2011 (Colonic Neoplasms...) : The suppressive activity of tumor associated Foxp3 ( + ) CD4 ( + ) CD25 ( + ) regulatory T cells ( Treg ) was IL-10 dependent
Reilkoff et al., Am J Respir Crit Care Med 2013 (Disease Models, Animal...) : In comparison to Sema 7a-CD4 ( + ) CD25 ( + ) FoxP3 ( + ) cells, Sema7a ( + ) CD4 ( + ) CD25 ( + ) FoxP3 ( + ) cells exhibit reduced expression of regulatory genes such as IL-10 , and adoptive transfer of these cells induces fibrosis and remodeling in the TGF-ß1 exposed murine lung
Yi et al., J Hepatol 2013 : Moreover, isolated HCC infiltrating CD4 ( + ) CD25 ( + ) regulatory T cells ( Treg cells ) directly suppressed the cytotoxic function and IFN-? secretion of ?d T cells in a TGFß- and IL-10 dependent manner
Xavier et al., PLoS Pathog 2013 (Brucellosis) : Here, we show that the persistent intracellular pathogen Brucella abortus prevents immune activation of macrophages by inducing CD4 ( + ) CD25 ( + ) T cells to produce the anti-inflammatory cytokine interleukin-10 (IL-10) early during infection
Shirakawa et al., Mol Cell Biol 1989 : Identical results were obtained with the human natural killer-like cell line YT, which can be induced to express the interleukin-2 receptor alpha subunit in response to interleukin-1 , cyclic AMP, or phorbol 12-myristate 13-acetate
Burlinson et al., Immunol Lett 1995 : IL-4 is the only cytokine apparently capable of promoting CD25 expression in human high-density quiescent tonsillar B cells ; neither IL-10 nor IL-13 could induce CD25 expression
Körholz et al., Blood 1997 : Exogenously administered IL-10 significantly reduced the IL-15 and IL-2 mediated IFN-gamma and TNF-alpha production, whereas T-cell proliferation and CD25 expression were not affected