◀ Back to GSK3B
GSK3B — PRKCB
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., Neoplasia (New York, N.Y.) 2006
(Colonic Neoplasms) :
The effect of NT was blocked by inhibitors of protein kinase C ( PKC ), but not by inhibitors of MEK1 or phosphatidylinositol-3 kinase, suggesting a predominant role for PKC in GSK-3beta phosphorylation by NT. Pretreatment with Gö6976 ( which inhibits PKCalpha and PKCbeta1 ) or downregulation of endogenous PKCalpha or
PKCbeta1 blocked NT-mediated
GSK-3beta ( but not GSK-3alpha ) phosphorylation ... Moreover, a selective PKCbeta inhibitor, LY379196, reduced NT-mediated GSK-3beta ( but not GSK-3alpha ) phosphorylation, suggesting a
role for
PKCbeta1 in the NT-mediated phosphorylation of
GSK-3beta and an undefined kinase in the NT-mediated phosphorylation of GSK-3alpha
Furlong et al., American journal of physiology. Renal physiology 2007
(Diabetic Nephropathies...) :
We show that inhibition of
PKC-beta with LY379196 and PKC-beta siRNA
reduced basal PKC-zeta and
GSK3beta phosphorylation in human mesangial cells exposed to high glucose