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CRTC1 — TSC1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 78 proteins (association, tandem affinity purification) Gloeckner et al., Proteomics 2007

Text-mined interactions from Literome

DeYoung et al., Genes Dev 2008 (Breast Neoplasms) : Genetic studies have shown the tuberous sclerosis tumor suppressors TSC1/2 and the REDD1 protein to be essential for hypoxia regulation of TORC1 activity in Drosophila and in mammalian cells
Hoogeveen-Westerveld et al., Hum Mutat 2012 (Tuberous Sclerosis) : Our functional assessment identified four substitutions ( p.L61R, p.G132D, p.F158S, and p.R204P ) between amino acids 50 and 224 that reduced TSC1 stability and prevented the TSC1-TSC2 dependent inhibition of TORC1