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HSP90AA1 — STAT3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
STAT3
—
HSP90AA1
(physical association, affinity chromatography technology)
Sato et al., Biochem Biophys Res Commun 2003*
-
IRef Hprd Interaction:
STAT3
—
HSP90AA1
(in vivo)
Sato et al., Biochem Biophys Res Commun 2003*
-
IRef Intact Interaction:
Complex of 12 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of 306 proteins
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Ophid Interaction:
STAT3
—
HSP90AA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
STAT3
—
HSP90AA1
(aggregation, confirmational text mining)
Sato et al., Biochem Biophys Res Commun 2003*
Text-mined interactions from Literome
Stephanou et al., Gene Expr 1999
:
In contrast,
STAT-3 and HSF-1 antagonize one another and
reduce the activation of both the Hsp70 and
Hsp90 promoters
Metge et al., J Biol Chem 2004
:
Investigation into the role of Stat3 signaling during centrosome production demonstrated that
Stat3 does not directly
regulate the transcription of the
centrosome genes encoding gamma-tubulin and PCM-1
Valdez et al., Leuk Res 2008
(Leukemia, Myeloid) :
Furthermore, Bu resistance in these cells may be attributed in part to up-regulation of
HSP90 protein and
activation of
STAT3 ... The inhibition of
HSP90 with geldanamycin
attenuated phosphorylated
STAT3 and made B5/Bu250 ( 6 ) and KBM3/Bu250 ( 6 ) more Bu-sensitive
Hackl et al., Surgery 2010
(Acute Disease...) :
Inhibition of
HSP90 effectively
diminished the constitutive phosphorylation of Akt, Erk, and
STAT3 in PHHs. Conversely, inhibition of HSP90 significantly increased the expression of both VEGF and HGF mRNA, and induced HSP70 protein in PHH cultures in vitro
Fu et al., PloS one 2012
(Carcinoma...) :
Hsp90 interacts with STAT3 and
stabilizes Tyr phosphorylated
STAT3 ... We found that overexpression of
Hsp90 inhibited luteolin induced degradation of Tyr ( 705 ) -phosphorylated
STAT3 and luteolin also reduced the levels of some other Hsp90 interacting proteins
Giordano et al., Mol Oncol 2013
:
Leptin increases HER2 protein levels through a
STAT3 mediated up-regulation of
Hsp90 in breast cancer cells
Stephanou et al., J Biol Chem 1999
:
The effect of IFN-gamma/STAT-1 was mediated via a short region of the
Hsp-70/Hsp-90 promoters, which also
mediates the effects of NF-IL6 and
STAT-3 and can bind STAT-1