◀ Back to STAT3
SP1 — STAT3
Pathways - manually collected, often from reviews:
-
FastForward regulation:
SP1
→
STAT3
(transcriptional regulation, unknown)
Evidence: DNABINDING
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Loeffler et al., Int J Cancer 2005
(Glioblastoma) :
Interestingly, preincubation with STAT3 antibody prevented the binding of Sp1 and Sp3 to the -88/-50 element, indicating that
STAT3 is
involved in IL-6-driven
Sp1/Sp3 protein-DNA complex formation
Tapias et al., Cell cycle (Georgetown, Tex.) 2008
:
Among the known Sp1 interacting proteins, E2F-DP1, Cyclin D1,
Stat3 and Rb
activated the
Sp1 promoter, whereas p53 and NF kappaB inhibited it
Su et al., Am J Physiol Cell Physiol 2009
:
Cell confluency induced
Stat3 activation
regulates NHE3 expression by recruiting
Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation ... Thus, during confluency, ligand independent
Stat3 activation
leads to its interaction with
Sp1/Sp3 , their recruitment to the SpA/B/C cluster in a Stat3 DNA binding domain dependent fashion, increased transcription, and expression of NHE3, to coordinate cell density mediated epithelial dome formation