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EOMES — IFNG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Suto et al., J Immunol 2006
:
Moreover, the repression of
Eomes expression by IL-21 is not
due to an indirect effect of IL-21 on the expression of
IFN-gamma or STAT4 and is independent of STAT1 and T-bet expression ... Finally, we show that ectopic expression of
Eomes prevents the inhibition of
IFN-gamma production from IL-21 treated Thp cells ... Taken together, these results demonstrate that
Eomes plays a role in regulating IFN-gamma production in CD4+ T cells and IL-21
inhibits IFN-gamma production in developing Th1 cells through the repression of Eomes expression
Atreya et al., Gut 2007
(Colorectal Neoplasms...) :
Whereas overexpression of this factor induced perforin but not granzyme expression, siRNA mediated suppression of
eomesodermin expression
led to significantly reduced
IFN-gamma production, perforin levels and cytolytic activity of CD8 T cells
Cruz-Guilloty et al., J Exp Med 2009
:
Runx3
regulates Eomes expression as well as expression of three cardinal markers of the effector CTL program
: IFN-gamma , perforin, and granzyme B
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010
:
Both T-bet and
Eomes may simultaneously be
involved in the regulation of the
IFN-gamma production of gammadeltaT cells
Yagi et al., Immunity 2010
:
Another T-box containing transcription factor
Eomes , but not T-bet, was
induced both in GATA3-deficient CD4 ( + ) T cells differentiated under Th2 cell conditions and in Th2 cells with enforced Runx3 expression, contributing to
IFN-gamma production
He et al., J Immunol 2010
(Melanoma, Experimental) :
Consistently, transfection of dominant negative
Eomes in Vgamma4 gammadelta T cells
diminished the level of
IFN-gamma secretion, indicating a critical role of Eomes in the effector function of these gammadelta T cells