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HRAS — RASGRF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HRAS → RASGRF1 (increases, RASGRF1 Activity, HRAS Activity) Mattingly et al., J Biol Chem 1999*
  Evidence: Site-directed mutagenesis replaced each of the serine residues within this region with alanine and demonstrated that serine 916 is a major site of in vivo phosphorylation of Ras-GRF1 in both COS-7 cells and NIH-3T3 fibroblasts.
• KEGG MAPK signaling pathway: RASGRF1/RASGRF2 → HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2 (protein-protein, activation)
  
• NCI Pathway Database CDC42 signaling events: RASGRF1 (RASGRF1) → HRAS/GTP complex (HRAS) (modification, activates) Arozarena et al., J Biol Chem 2000*, Arozarena et al., J Biol Chem 2001*
  Evidence: assay
• NCI Pathway Database CDC42 signaling events: RASGRF1 (RASGRF1) → HRAS/GDP complex (HRAS) (modification, activates) Arozarena et al., J Biol Chem 2000*, Arozarena et al., J Biol Chem 2001*
  Evidence: assay
• NCI Pathway Database Regulation of Ras family activation: RASGRF1 (RASGRF1) → HRAS/GTP complex (HRAS) (modification, activates) Anborgh et al., Mol Cell Biol 1999, Mattingly et al., J Biol Chem 1999*, Yang et al., J Biol Chem 2003*, Caloca et al., J Biol Chem 2003, Shou et al., Nature 1992*, Arozarena et al., Mol Cell Biol 2004*, Freedman et al., Proc Natl Acad Sci U S A 2006*, Buday et al., Biochim Biophys Acta 2008*, Calvo et al., Mol Biol Cell 2009*, Schweighoffer et al., Oncogene 1993*, Wei et al., Gene 1994*, Gotoh et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of Ras family activation: RASGRF1 (RASGRF1) → HRAS/GDP complex (HRAS) (modification, activates) Anborgh et al., Mol Cell Biol 1999, Mattingly et al., J Biol Chem 1999*, Yang et al., J Biol Chem 2003*, Caloca et al., J Biol Chem 2003, Shou et al., Nature 1992*, Arozarena et al., Mol Cell Biol 2004*, Freedman et al., Proc Natl Acad Sci U S A 2006*, Buday et al., Biochim Biophys Acta 2008*, Calvo et al., Mol Biol Cell 2009*, Schweighoffer et al., Oncogene 1993*, Wei et al., Gene 1994*, Gotoh et al., J Biol Chem 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RASGRF1 (RASGRF1) (modification, collaborate) Yang et al., Mol Biol Cell 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RASGRF1 (RASGRF1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Yang et al., Mol Biol Cell 2006
  Evidence: mutant phenotype, assay, other species
• Reactome Reaction: HRAS → RASGRF1 (reaction) Krapivinsky et al., Neuron 2003
• WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling: RASGRF1 → HRAS/KRAS/NRAS (activation) Arozarena et al., Mol Cell Biol 2004*
• WikiPathways p38 MAPK Signaling Pathway: SHC1/GRB2/RASGRF1 → HRAS (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HRAS — RASGRF1 (direct interaction, two hybrid) Stang et al., Mol Cell Biol 1997*

Text-mined interactions from Literome

Gotoh et al., J Biol Chem 2001 : Here we show that whereas Ras-GRF1 activated both Ha-Ras and R-Ras in cells, Ras-GRF2 activated only Ha-Ras
Arozarena et al., Mol Cell Biol 2004 : With the aid of H-Ras constructs specifically tethered to the plasma membrane, endoplasmic reticulum, and Golgi complex, we demonstrate that RasGRF1 and RasGRF2 can activate plasma membrane and reticular, but not Golgi associated, H-Ras
Yang et al., Mol Biol Cell 2006 : These results suggest that coordinated activation of H-Ras and Rac1 by Ras-GRF1 may be a significant controller of neuronal cell size
Zhu et al., J Biol Chem 2007 (MAP Kinase Signaling System...) : Experimental evidence indicated that this phenomenon was associated with destabilization and ubiquitylation of Ras-GRF1 , a guanine nucleotide exchange factor that activates H-Ras by facilitating the release of GDP
Jones et al., J Biol Chem 1998 : We found that Ras-GRF/Cdc25Mm activates Ha-Ras , but does not activate N-Ras or K-Ras 4B, protein in vivo