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PTGS2 — TCF19

Text-mined interactions from Literome

Howe et al., Cancer Res 1999 (Breast Neoplasms...) : Expression of the inducible prostaglandin synthase cyclooxygenase-2 appears critical for intestinal tumorigenesis resulting from APC mutation, suggesting that cyclooxygenase-2 might be a transcriptional target for beta-catenin/Tcf complexes
Chen et al., Life Sci 1999 : These results suggest that the transcriptional regulation of COX-2 expression by NF-kappaB depends upon the types of cells studied and that activation of this transcription factor alone does not play an important role in the expression of COX-2 in rat smooth muscle cells
Yuan et al., Cancer Res 2000 : Here, we report that a transcription factor , CCAAT/enhancer binding protein beta ( C/EBPbeta ), plays a critical role in sPLA2IB induced, receptor mediated COX-2 gene expression in MC3T3E1 and NIH3T3 cells
Guo et al., J Biol Chem 2001 (Cell Transformation, Neoplastic...) : Activator protein-1 transcription factor mediates bombesin stimulated cyclooxygenase-2 expression in intestinal epithelial cells
Meyer-Siegler et al., Mol Med 2001 (Prostatic Neoplasms) : These data suggest that COX-2 inhibition induces NF-kappa beta transcription factor activation, which subsequently induces pro-inflammatory protein expression ( COX-2 and MIF ) and neuroendocrine differentiation in the LNCaP C4-2b subline
Lee et al., Eur J Neurosci 2004 (Hyperalgesia...) : Moreover, the transcription factor , nuclear factor-kappa B (NF-kB), regulates the expressions of both COX-2 and dynorphin
Cherukuri et al., Cancer Biol Ther 2005 (Colorectal Neoplasms) : These results suggest that Se-Met regulates COX-2 at transcriptional level by modulating the activity of NF-kappaB transcription factor
Sharma et al., Cancer Res 2005 (Carcinoma, Lewis Lung...) : Tumor derived COX-2/PGE2 induced expression of the Treg cell-specific transcription factor , Foxp3, and increased Treg cell activity
Flora et al., Neuromolecular Med 2006 (Inflammation) : Tat induced COX-2 expression was partially prevented by pyrrolidine dithiocarbamate, a potent antioxidant and an inhibitor of the transcription factor , nuclear factor kappaB
Vij et al., Am J Respir Cell Mol Biol 2008 (Cystic Fibrosis) : The inhibition of Cox-2 signaling led to down-regulation of the downstream C/EBP homologous protein (CHOP) transcription factor , resulting in a decrease in IL-8 activation
Rajapakse et al., Immunology 2008 : The data from the nuclear factor-kappaB (NF-kappaB) promoter gene transfection experiment supported the idea that inhibition of iNOS and COX-2 is caused by the down-regulation of their transcription factor , NF-kappaB
Lee et al., Exp Mol Med 2008 : Also, COX-2 overexpression caused suppression of SOX-9 expression, a major transcription factor that regulates type II collagen expression, as indicated by the Western blot and RT-PCR
Park et al., Mol Cell Endocrinol 2012 : The present study investigated the role of RUNX2 transcription factor in regulating the expression of Runx1, Ptgs2 , and Tnfaip6 using cultured granulosa cells isolated from PMSG primed immature rats
Chen et al., Am J Physiol 1997 : The role of nuclear factor (NF)-kappaB transcription factor in silica induced cyclooxygenase (COX) II gene expression was examined in the rat alveolar macrophage cell line NR8383