UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PTPN11

HCK — PTPN11

Pathways - manually collected, often from reviews:

NCI Pathway Database IL6-mediated signaling events: SHP2 (PTPN11) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK) (modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction