O'Neill et al., Immunity 2008
:
The tyrosine phosphatase SHP1 has been shown to positively regulate induction of interferon-beta, whereas SHP2 inhibits the kinase TBK1 , limiting this response
Tanaka et al., Arch Biochem Biophys 2010
(Stomach Neoplasms) :
In addition, the level of phosphorylated IRF3 decreased in CagA overexpressing DC stimulated with LPS, indicating that activated SHP-2 suppressed the enzymatic activity of TBK1 and consequently IRF3 phosphorylation