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CXCR3 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCR3 → TNF (increases) Mach et al., J Clin Invest 1999*
  Evidence: In vitro experiments supported these results and showed that IL-1beta, TNF-alpha, and CD40 ligand potentiated IP-10 expression from IFN-gamma-stimulated ECs.
• OpenBEL Selventa BEL large corpus: CXCR3 → TNF (increases, TNF Activity)
  Evidence: the CXC chemokines Mig and interferon-? inducible protein 10 can be expressed and bound by endothelium stimulated with interferon-? and tumor necrosis factor (TNF) ?, and can induce the firm adhesion of T lymphocyte in shear flow via CXCR3.

Text-mined interactions from Literome

Venza et al., J Periodontol 2010 (Chronic Periodontitis...) : These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha, CCR5, and CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes affected the expression of TNF-alpha , IL-6 and -8, CCR5, and CXCR3
Zhang et al., J Neuroimmunol 2010 (West Nile Fever) : TNF-alpha dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis
Hilda et al., FEMS Immunol Med Microbiol 2012 : Increased expression of CD32, CD64, TLR4, and CXCR3 ; increased TNF-a secretion ; and downregulation of early apoptosis were observed in H37Rv infected neutrophils
Venkatesh et al., Immunity 2013 (Inflammation...) : We showed that acute stimulation of murine microvascular endothelial cells expressing the tumor necrosis factor receptors TNFR1 and TNFR2 with the soluble cytokine TNF led to CXCR3 chemokine generation
Asagoe et al., J Immunol 1998 : In contrast, CXCR1 expression was not affected by TNF-alpha