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PDC — SETD2

Text-mined interactions from Literome

Shen et al., J Orthop Res 2009 (Femoral Fractures) : Small molecule inhibitors of the prolyl hydroxylase enzyme (PHD) , the key enzyme responsible for degrading HIF-1, have been shown to activate HIF-1 , and are effective in inducing angiogenesis
Brökers et al., Cancer Sci 2010 : Taken together, our data indicate that PHD inhibitors might increase chemoresistance of tumor cells in a HIF-1 dependent manner
Lu et al., PloS one 2010 : This downregulatory effect was abolished when the oxygen dependent domain (ODD) of HIF-1a ( HIF-1a-dODD, the domain responsible for HIF-1a degradation ) was experimentally deleted or when the activity of HIF-1a prolyl hydroxylase (PHD) or the 26S proteasomal complex was inhibited, indicating that the 1, 9 PA downregulates HIF-1a by promoting PHD dependent HIF-1a degradation
Glushakova et al., Mol Genet Metab 2011 (Pyruvate Dehydrogenase Complex Deficiency Disease) : Increased HIF1a expression may contribute to the increase in glycolytic flux and lactate production in PDC deficiency and, by trans activating pyruvate dehydrogenase kinase, may further suppress residual PDC activity through phosphorylation of the E1a subunit
Łuczak et al., Oncol Rep 2011 (Uterine Cervical Neoplasms) : Under hypoxic stress, proline hydroxylase (PHD) activity is diminished, and stabilized HIF-1A is involved in the activation of the tissue response to hypoxia
Agis et al., J Periodontal Res 2012 : Independently from this response, PHD inhibitors stabilized HIF-1a and increased the production of VEGF
Ogle et al., Neurobiol Dis 2012 (Brain Ischemia) : The present investigation tested the therapeutic potential of enhanced activation of oxygen sensing pathways by competitive pharmacologic PHD inhibition after stroke, hypothesizing that post-ischemic PHD inhibition would reduce neuronal cell death and require the activation of HIF-1a
Ahmad et al., Am J Respir Cell Mol Biol 2012 (Airway Remodeling...) : Oxygen sensing prolyl-hydroxylase (PHD)-2 negatively regulates hypoxia-inducible factor (HIF)1-a and suppresses the hypoxic response
Niecknig et al., Free radical research 2012 : Herein, modulation of PHD activity appeared to be the key element, because knockdown and inhibition of the PHD2 prevented reduction of HIF-1a
Fujita et al., J Biol Chem 2012 (Intervertebral Disc Displacement) : In contrast, in hypoxia, PHD3 enhances HIF-1a transcriptional activity without affecting protein levels
Sutendra et al., Oncogene 2013 (Neoplasms...) : Using pharmacologic and molecular approaches that suppress the prolyl-hydroxylase (PHD) mediated inhibition of HIF1a , we show that DCA inhibits HIF1a by both a PHD dependent mechanism ( that involves a DCA induced increase in the production of mitochondria derived a-ketoglutarate ) and a PHD independent mechanism, involving activation of p53 via mitochondrial derived H2O2, as well as activation of GSK3ß
Barnucz et al., J Pharmacol Exp Ther 2013 (Disease Models, Animal...) : Reduction of PHD activity during hypoxia leads to stabilization and accumulation of hypoxia inducible factor (HIF) 1a