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ANGPT2 — KLF5
Text-mined interactions from Literome
Bafford et al., Surgery 2006
(Hyperplasia) :
Stimulation of VSMC with
Ang II and TNF-alpha
led to a rapid upregulation of
KLF5 expression, and a later increase in SVV, which was cell-cycle independent
Gao et al., Biol Pharm Bull 2006
:
In this study, we showed that in growth arrested vascular smooth muscle cells ( VSMCs ),
Ang II induced cell proliferation, KLF5 mRNA and protein expression in a dose- and time dependent fashion, whereas
KLF5 mRNA stability was not affected ... These data, for the first time, revealed the involvements of some intracellular signals in the regulation of
KLF5 expression in
response to
Ang II in VSMCs and showed the possible role of KLF5 in Ang II-induced cell proliferation in VSMCs