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ESR1 — IRS1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Morelli et al., Oncogene 2004
:
Transcription reporter assays with E2-sensitive promoters suggested that the presence of
IRS-1 inhibits
ERalpha activity at estrogen-responsive element containing DNA
Surmacz et al., J Exp Clin Cancer Res 2004
(Breast Neoplasms) :
Most notably, activation of
ERalpha upregulates the expression of
IRS-1 , IGF-IR, and IGF-1, which results in amplification of IGF-I responses
Townson et al., Biochem Biophys Res Commun 2006
:
Consequently, we asked whether RFP would modulate ESR1 activity and we discovered that RFP was important for the
ESR1 dependent expression of cyclin D1 (CCND1) and the progesterone receptor (PR), but not
IRS1 or MYC
Sisci et al., Ann Oncol 2007
(Breast Neoplasms) :
IRS-1 knock down abrogated IGF-1 dependent transcriptional activity of unliganded ERalpha, but
induced the activity of liganded
ERalpha ...
ERalpha/IRS-1 interactions are direct and
involve the ERalpha AF-1/DBD domain and
IRS-1 domains mapping within N- and C-terminus