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APOB — VEGFA
Text-mined interactions from Literome
Inoue et al., Arterioscler Thromb Vasc Biol 2001
(Arteriosclerosis) :
Oxidized
LDL regulates
vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator activated receptor-gamma ... Therefore, we investigated the involvement of PPARgamma in the
regulation of
VEGF by
Ox-LDL ... TRO and
Ox-LDL augmented
VEGF expression in U937T ... In conclusion,
Ox-LDL upregulates
VEGF expression in macrophages and endothelial cells, at least in part, through the activation of PPARgamma
Salomonsson et al., Eur J Clin Invest 2002
(MAP Kinase Signaling System) :
Post-transcriptional
regulation of
VEGF expression by oxidised
LDL in human macrophages
RodrĂguez et al., Cardiovasc Res 2005
(Hypercholesterolemia) :
Vitamins C and E prevent endothelial
VEGF and VEGFR-2 overexpression
induced by porcine hypercholesterolemic
LDL ...
HC-LDL , with high cholesterol ( P < 0.05 ) and reduced tocopherol/cholesterol ratio ( P < 0.05 ),
increased significantly
VEGF and VEGFR-2 ( p < 0.001 ) in EC, associated with higher O ( 2 ) ( - ) and HIF-1 alpha expression, in comparison with C-LDL and HCV-LDL ... Our data suggest
HC-LDL induce endothelial
VEGF and VEGFR-2 overexpression at least by increasing oxidative stress, and HIF-1 alpha is one of the signaling mechanisms involved
Trapé et al., Scand J Clin Lab Invest 2006
(Atherosclerosis...) :
VEGF expression is
regulated by hypoxia, cytokines, oncogenes, and oxidized
low-density lipoprotein (LDL)
Kanata et al., Biochem Biophys Res Commun 2006
:
Oxidized
LDL binding to LOX-1
upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma ...
Ox-LDL markedly
increased VEGF mRNA expression and protein release in time- and dose dependent manners, which was significantly suppressed by anti-LOX-1 antibody pretreatment ... The specific PPAR-gamma inhibitor GW9662 suppressed
ox-LDL induced
VEGF expression
Usui et al., EMBO Rep 2007
:
Here we report that native
LDL ( nLDL )
activates vascular endothelial growth factor ( VEGF ) receptor 1 ( VEGFR1 ) but not VEGFR2 through LDLR and is as potent as VEGF in macrophage migration
Moreira et al., Invest Ophthalmol Vis Sci 2009
(Choroidal Neovascularization) :
In ARPE19 cells and HMVECs, oxidized
LDL and 7kCh
induced VEGF 8- to 10-fold above controls
Liu et al., Phytomedicine 2009
(Atherosclerosis) :
The aim of this study was to investigate whether
Ox-LDL regulates
VEGF expression in human THP-1 monocytes, as well as the effect of EGb 761 on VEGF expression and the formation of foam cells ...
Ox-LDL markedly
increased VEGF expression in THP-1 cells in a time- and concentration dependent manner, which was significantly suppressed by EGb 761
Kuzuya et al., Nihon Ronen Igakkai Zasshi 1998
(Arteriosclerosis) :
In the present study, we examined the
role of inflammatory cytokines and oxidative modified low density lipoprotein (
OX-LDL ) in the expression of macrophage
VEGF
Ramos et al., Arterioscler Thromb Vasc Biol 1998
(Arteriosclerosis) :
Induction of macrophage
VEGF in
response to oxidized
LDL and VEGF accumulation in human atherosclerotic lesions ... The current study demonstrated that Ox-LDL upregulated
vascular endothelial growth factor ( VEGF ) mRNA expression in RAW 264 cells, a monocytic cell line, in a time- and concentration dependent manner and that
Ox-LDL stimulated VEGF protein secretion from the cells