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SERPINE1 — VEGFA

Text-mined interactions from Literome

Kim et al., J Cell Biochem 2003 (Neovascularization, Pathologic) : VEGF and bFGF stimulation also significantly induced uPA expression, most strikingly the level of 33 kDa uPA, and increased the expression of PA inhibitor (PAI)-1
Wu et al., Am J Physiol Cell Physiol 2004 (Keloid...) : We have further demonstrated that VEGF stimulated the expression of PAI-1 , but not urokinase plasminogen activator (uPA), in keloid fibroblasts at both mRNA and protein levels, in a dose- and time dependent manner ... Additionally, we have characterized for the first time that the extracellular signal regulated kinase ( ERK ) 1/2 signaling pathway is mainly involved in VEGF induced PAI-1 expression and have demonstrated its potential as a target molecule for modulation of scar fibrosis
Hjortland et al., Exp Cell Res 2004 (Glioma) : Plasminogen activator inhibitor-1 increases the expression of VEGF in human glioma cells
Pepper et al., Biochem Biophys Res Commun 1991 : In addition, VEGF induced u-PA and PAI-1 mRNAs with kinetics similar to those previously demonstrated for bFGF ... These results demonstrate the regulation of PA and PAI-1 production by VEGF in microvascular endothelial cells and are in accord with the hypothesis that extracellular proteolysis, appropriately balanced by protease inhibitors, is required for normal capillary morphogenesis