Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RAF1
→
RAP1A
(increases, RAP1A Activity, RAF1 Activity)
Evidence: as shown in Figure 2.95-98 In essence, the activation status of Raf depends on the integration of both activating and inhibitory stimuli, the net result of which determines the downstream messages. THE RAF FAMILY OF GENES AND PROTEINS The raf family of genes was first identified as oncogenes in retroviruses that are the causative vectors of tumors in mice and chicken.99,100 The first raf gene to be identified, v-raf, the transforming gene of the mouse sarcoma virus 3611, induces fibrosarcomas an...