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EPHB2 — KCNH4

Text-mined interactions from Literome

Garcia et al., Mol Cell Biol 2001 : Indeed, ( i ) in cells expressing wild-type or mutant Mpl, TPO induced Ras and Rap1 activation correlates with early and sustained phases of ERK signal, respectively ; ( ii ) interfering mutants of Ras and Rap1 both inhibit ERK kinase activity and ERK dependent Elk1 transcriptional activation in response to TPO ; ( iii ) the kinetics of activation of Raf-1 and B-Raf by TPO follow those of Ras and Rap1, respectively ; ( iv ) RasV12 mediated Elk1 activation was modulated by the wild type or interfering mutants of Raf-1 but not those of B-Raf ; ( v ) Elk1 activation mediated by a constitutively active mutant of Rap1 ( Rap1V12 ) is potentiated by B-Raf and inhibited by an interfering mutant of this kinase
Zhang et al., Biochem Biophys Res Commun 2002 : Overexpression of Naf1 alpha suppressed ERK2 entering into the nucleus and inhibited the ERK2 dependent Elk1-driven luciferase transcription, suggesting Naf1 alpha to be an attenuator of activated ERK2 signaling
Yang et al., Mol Cell 2003 : ERK pathway activation leads to both phosphorylation of Elk-1 and loss of SUMO conjugation and, hence, to the loss of the repressive activity of the R motif
Bourguignon et al., J Biol Chem 2005 (Disease Progression...) : The activated ERK2 then increased the phosphorylation of both Elk-1 and estrogen receptor-alpha (ER alpha), resulting in Elk-1- and estrogen-responsive element mediated transcriptional up-regulation ... Down-regulation of IQGAP1 ( by treating cells with IQGAP1-specific small interfering RNAs ) not only blocked IQGAP1 association with CD44, Cdc42, F-actin, and ERK2 but also abrogated HA-CD44 induced cytoskeletal function, ERK2 signaling ( e.g. ERK2 phosphorylation/activity, ERK2 mediated Elk-1/ER alpha phosphorylation, and Elk-1/ER alpha-specific transcriptional activation ), and tumor cell migration
Harii et al., Mol Endocrinol 2005 (Thyroiditis, Autoimmune...) : In this report, we demonstrate TLR3 mRNA and protein are expressed on Fisher rat thyroid cell line-5 ( FRTL-5 ) thyroid cells and are functional because incubating cells with polyinosine-polycytidylic acid causes 1 ) transcriptional activation of both the nuclear factor kappaB (NF-kappaB)/Elk1 and interferon (IFN) regulatory factor-3/IFN-beta signal paths, 2 ) posttranscriptional activation of NF-kappaB and ERK1/2 , and 3 ) increased IFN-beta mRNA
Adams et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Pharmacological inhibitor studies as well as reporter assays for ERK dependent activation of the transcription factor Elk1 revealed that the PP2A holoenzymes ABalphaC and ABdeltaC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade
Wu et al., J Cell Biochem 2006 : The ERK inhibitor ( PD98059 ) blocked Elk-1 phosphorylation, as well as COL1 and OPN gene expression
Karhoff et al., Neuroendocrinology 2007 (Digestive System Neoplasms...) : Overexpression of Rap1 and B-Raf activated MAPK extracellular dependent kinase (ERK) ERK-2 and ERK dependent transcription factor Elk-1 in neuroendocrine cell lines Bon and INS-1
Tsai et al., J Bone Miner Res 2007 (MAP Kinase Signaling System) : We found that hypertonicity resulted in phosphorylation and activation of ERK1/2 proteins and concomitant activation of C terminus TAD activity of ELK-1 , a downstream transcription factor
Cohen-Armon et al., Trends Pharmacol Sci 2007 : Furthermore, ERK2 induced PARP-1 activation dramatically amplifies ERK-signals, enhancing ERK induced phosphorylation of the transcription factor Elk1 and enhancing core histone acetylation and expression of the Elk1 target gene, c-fos
Wei et al., Virology 2009 : The PCV2 induced ERK1/2 leads to phosphorylation of the ternary complex factor Elk-1 , which kinetically paralleled ERK1/2 activation
Liu et al., Mol Cell Biol 2011 : Interference of p300 dependent acetylation of ATF5 or nucleosomal histone H3 or blockade of ERK dependent Elk-1 phosphorylation abrogates ATF5 dependent Egr-1 activation and cell proliferation and survival
Besnard et al., J Neurosci 2011 : In response to cocaine, ERK controls the phosphorylation levels of both mitogen and stress activated protein kinase 1 ( MSK-1 ), a nuclear kinase involved in histone H3 ( Ser10 ) and cAMP response element binding protein phosphorylation, and Elk-1 , a transcription factor involved in serum response element ( SRE ) -driven gene regulations
Larsen et al., J Biol Chem 1998 : Hyperosmolarity caused phosphorylation of Elk-1 , activation transcription factor 2, and heat shock protein 25 and activation of ERK1/2 and p38 in islets comparable to that induced by IL-1beta but did not lead to NO synthesis