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EPHB2 — PTPN7
Text-mined interactions from Literome
Saxena et al., J Biol Chem 1999
:
Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that
HePTP acts directly on the mitogen activated protein ( MAP ) kinases
Erk1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells
Pettiford et al., Oncogene 2000
:
Together, these data identify ERK2 as a specific and direct target of HePTP and are consistent with a model in which
HePTP negatively
regulates ERK2 activity as part of a feedback mechanism
Pettiford et al., Leukemia 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
The protein tyrosine phosphatase
HePTP regulates nuclear translocation of
ERK2 and can modulate megakaryocytic differentiation of K562 cells ... However, antisense inhibition of
HePTP enhanced nuclear translocation of
ERK and the expression of the megakaryocytic markers CD41 and IL-6 ... They further show that
HePTP is
involved in the regulation of nuclear translocation of
ERK2 and that HePTP protein levels can modulate K562 cell differentiation
Sergienko et al., ACS Chem Biol 2012
:
Here, we report the development of a small molecule that
augments ERK1/2 and p38 activation in human T cells, specifically by inhibiting
HePTP