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IL1B — LEP

Text-mined interactions from Literome

Reichlin et al., Endocrinology 2000 : IL-1beta by either the iv or icv route significantly increased leptin levels in the aorta [ 1.19+/-0.10 vs. 1.92+/-0.15 ng/ml ( P = 0.0002 ) and 1.19+/-0.10 vs. 1.57+/-0.12 ng/ml ( P = 0.022 ), respectively ] ... These findings demonstrate a net uptake of leptin by the cerebral cortex from peripheral blood in both normal and IL-1beta treated animals and show that peripheral blood levels of leptin are increased by IL-1beta whether administered icv or iv
Hosoi et al., Biochem Biophys Res Commun 2000 : Expression of leptin receptors and induction of IL-1beta transcript in glial cells ... To examine the role of leptin in the immune function of the brain, we examined the effect of leptin on interleukin-1beta (IL-1beta) expression in mouse primary cultured glial cells ... These results indicate that leptin could induce IL-1beta transcript in the brain and that one of the target cells of the leptin induced IL-1beta transcript may be a glial cell
Hosoi et al., Am J Physiol Regul Integr Comp Physiol 2002 (Encephalitis) : Subdiaphragmatic vagotomy fails to inhibit intravenous leptin induced IL-1beta expression in the hypothalamus ... In the present study, we investigated whether intravenous leptin induced IL-1beta expression in the hypothalamus is mediated via afferent vagus nerve ... Subdiaphragmatic vagotomy did not significantly modify intravenous leptin induced IL-1beta expression in the hypothalamus compared with that in sham treated mice
Gonzalez et al., Endocrine 2001 : We also determined the regulatory effects of IL-1beta on leptin secretion and on the expression of leptin and leptin receptor at the protein level in both EEC and endometrial stromal cell ( ESC ) cultures ... The upregulation of beta3-integrin and leptin/leptin receptor expression by IL-1beta in EEC cultures indicates that both cytokines may be implicated in embryonic-maternal cross-talk during the early phase of human implantation
Bruun et al., Mol Cell Endocrinol 2002 : This could suggest that IL-1beta through a post-translational pathway induced an acute increase in leptin-secretion , perhaps through the release of leptin from a pre formed pool within the adipose tissue
Hosoi et al., Brain Res 2002 : Leptin regulates interleukin-1beta expression in the brain via the STAT3 independent mechanisms ... We report here that peripherally applied leptin increased interleukin (IL)-1beta transcripts in many regions of the brain such as the hypothalamus, the hippocampus, the cortex, the cerebellum and the brainstem ... Although leptin did not induce STAT3 activation or suppressor of cytokine signaling3 ( SOCS3 ) expression in the hypothalamus of the db/db mice, which lack a functional Ob-Rb receptor, leptin increased the IL-1beta levels to similar extents as normal mice
Fain et al., Prostaglandins Leukot Essent Fatty Acids 2002 (MAP Kinase Signaling System) : Interleukin I(beta) further enhanced PGE ( 2 ) formation by adipocytes but did not affect leptin formation
Gonzalez et al., Mol Hum Reprod 2003 : Leptin stimulated IL-1 antagonist ( IL-1Ra ), IL-1beta secretion and expression of IL-1 receptor type I (IL-1R tI) in both cell types
Hosoi et al., Brain Res 2003 : Inhibition of leptin induced IL-1beta expression by glucocorticoids in the brain ... In the present study, we examined whether these neuroendocrine effects of glucocorticoids are linked to changes in the leptin induced expression of IL-1beta and STAT3 activation in the brain ... Pretreatment with dexamethasone dose dependently inhibited leptin induced IL-1beta expression in the hypothalamus ... Moreover, dexamethasone inhibited leptin induced IL-1beta expression in the primary cultured glial cells ... Therefore, it is suggested that glucocorticoid negatively regulates leptin induced IL-1beta expression in the brain
Wisse et al., Am J Physiol Endocrinol Metab 2004 (Body Weight...) : Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids : implications for energy homeostasis
Sachot et al., J Physiol 2004 (Anorexia...) : Previous studies have demonstrated that LPS induces leptin synthesis and secretion in the periphery, and that the action of leptin on appetite suppression and fever are dependent on brain interleukin (IL)-1beta
Simons et al., Cytokine 2005 : However, TNF-alpha, IL-1beta , and TGF-beta1 stimulated leptin production from preadipocytes in the absence of mature adipocytes ( 20.6+/-5.4 ng/ml, 100.8+/-18.2 ng/ml, and 5.4+/-0.4 ng/ml, respectively, compared to 6.6+/-0.8 ng/ml in control adipocyte cultures on day 21 ; n=4 )
Simons et al., J Endocrinol 2007 (Insulin Resistance) : Despite this reduction of lipid-laden adipocytes, TNF-alpha, IL-6/sIL-6R, and IL-1beta stimulated leptin release
Simopoulou et al., Osteoarthritis Cartilage 2007 (Obesity...) : Also, leptin had a detrimental effect on chondrocyte proliferation and induced IL-1beta production and MMP-9 and MMP-13 protein expression
Pinteaux et al., J Neurochem 2007 (Encephalitis) : Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism ... Recently we demonstrated that the effects of leptin are, at least in part, mediated by the release of interleukin (IL)-1beta in the brain ... In addition leptin induced IL-1beta release occurs via a signal transducer and activator of transcription 3 ( STAT3 ) -dependent mechanism ... Western blot analysis demonstrated that leptin induced the synthesis of pro-IL-1beta in microglial cells and the release of mature 17 kDa isoform into the culture medium ... Leptin induced IL-1beta release was neither inhibited by the pan-caspase inhibitor BOC-D-FMK, nor by the caspase 1 inhibitor Ac-YVAD-CHO indicating that IL-1 cleavage is independent of caspase activity ... These results confirm our earlier observations in vivo and demonstrate that microglia are an important source of IL-1beta in the brain in response to leptin
Maedler et al., FASEB J 2008 (Diabetes Mellitus, Type 2) : Chronic high glucose concentrations and leptin induce interleukin-1beta (IL-1beta) secretion from pancreatic islets, an event that is possibly causal in promoting beta-cell dysfunction and death
Johnston et al., Br J Dermatol 2008 (Chronic Disease...) : In vitro, both leptin and resistin could induce CXCL8 and tumour necrosis factor-alpha production by blood monocytes, and leptin could additionally induce IL-1beta and IL-1 receptor antagonist production
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : However, IL-1beta was only increased by leptin in benign primary-EEC
Fontana et al., Biocell 2010 : Interleukin-1 beta regulates metalloproteinase activity and leptin secretion in a cytotrophoblast model ... Here we investigated the effect of interleukin 1-beta on the activity of two important metalloproteinases ( MMP-2 and MMP-9 ) that are involved in extracellular matrix remodeling as well as the secretion of leptin , one of the reproductive hormones actively regulating their activity and secretion ... We found that IL-1 beta activates matrix metalloproteinase activity as well as increases leptin secretion
Wang et al., Curr Neurovasc Res 2010 (Anoxia) : GOSD induced IL-1beta was further enhanced by leptin in Akt/ERK dependent manner
Faggioni et al., Am J Physiol 1998 (Inflammation) : IL-1 beta mediates leptin induction during inflammation ... To investigate the role of IL-1 beta and IL-6 in leptin expression during inflammation, we used IL-1 beta-deficient ( -/- ) and IL-6 -/- mice ... We conclude that IL-1 beta is essential for leptin induction by both LPS and turpentine in mice, but IL-6 is not