◀ Back to NOS2

NOS2 — PLA2G4A

Text-mined interactions from Literome

Won et al., Glia 2005 : The inhibition of cPLA2 by methyl arachidonyl fluorophosphates ( MAFP ) or antisense oligomer against cPLA2 and inhibition of iPLA2 by bromoenol lactone reduced the LPS induced iNOS gene expression and NFkappaB activation ... These results indicate a role for cPLA2 and iPLA2 in LPS mediated iNOS gene induction in glial cells and the involvement of LO in these reactions
Ye et al., Am J Physiol Heart Circ Physiol 2006 (Myocardial Infarction...) : ATV induced eNOS phosphorylation and iNOS , cPLA2, and COX-2 expression, whereas Pio induced mainly the expression and activity of cPLA2
Pindado et al., J Immunol 2007 : Inhibition of cPLA2alpha expression and activity by either small interfering RNA ( siRNA ) or pyrrophenone leads to inhibition of the expression of the inducible NO synthase (iNOS) gene
Xu et al., J Biol Chem 2008 (Inflammation) : The iNOS induced cPLA(2)alpha activation is blocked by the specific iNOS inhibitor, 1400W ... Furthermore, COX-2 induction or expression markedly enhanced iNOS induced cPLA(2)alpha S-nitrosylation and activation, leading to 9-, 23-, and 20-fold increase of AA release and 100-, 38-, and 88-fold of PGE ( 2 ) production in A549, SG231, and HEK293 cells, respectively, whereas COX-2 alone leads to less than 2-fold change ... These results indicate that COX-2 has the ability to enhance iNOS induced cPLA(2)alpha S-nitrosylation and that maximal PG synthesis is achieved by the synergistic interaction among iNOS, cPLA(2)alpha, and COX-2
Lee et al., Biochem Biophys Res Commun 2007 : Inhibition of cPLA(2) activity by inhibitor attenuated the iNOS expression by CpG response