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NOS2 — PTX4
Text-mined interactions from Literome
Beshay et al., Clin Immunol 2001
(Autoimmune Diseases...) :
ROL and
PTX suppressed
inducible NO synthase at the mRNA level
Hoebe et al., Biochem Pharmacol 2001
:
In contrast,
PTX potentiated NO production and the expression of
inducible nitric oxide synthase (iNOS) in hepatocytes after stimulation with LPS
Kim et al., Gen Pharmacol 2000
:
In the present study, we observed that
pentoxifylline ( PTX ) significantly
augmented the nitric oxide ( NO ) production and the
iNOS gene expression by interleukin-1beta (IL-1beta) stimulated vascular smooth muscle cells ( VSMCs ) ... These results suggest that enhancing
effects of
PTX on the
iNOS gene expression in the IL-1beta stimulated VSMCs is mediated predominantly through the activation of NF-kappaB via cAMP dependent PKA pathway
Park et al., Int J Lepr Other Mycobact Dis 2001
:
Western blot analyses demonstrated that
iNOS was
suppressed by
PTX
Trajković et al., Immunology 1997
:
The aim of this study was to investigate
effects of
pentoxifylline ( PTX ) , a phosphodiesterase inhibitor with immunomodulatory properties, on NO production and
inducible NO synthase (iNOS) mRNA expression in rat astrocytes and macrophages
Vaziri et al., Am J Physiol 1998
(Kidney Failure, Chronic) :
Calcium channel blockade and
PTX lowered blood pressure, increased urinary NOX, and
enhanced vascular NOS activity, as well as eNOS and
iNOS protein expressions in the tested tissues