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POLDIP2 — TNFSF10

Text-mined interactions from Literome

Secchiero et al., Blood 2004 (MAP Kinase Signaling System) : Among the intracellular pathways investigated, TRAIL significantly stimulated the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the p38/mitogen activated protein kinase ( MAPK ) or the c-Jun NH2-terminal kinase (JNK) pathway
Sun et al., Int J Oncol 2011 : TRAIL induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt
Sun et al., Oncol Rep 2011 : MEKK1/MEKK4 are responsible for TRAIL induced JNK/p38 phosphorylation ... We found that MEKK1/MEKK4 as opposed to ASK1, are responsible for TRAIL induced c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation
Kavuri et al., J Biol Chem 2011 : Analyzing non-apoptotic signaling pathways, we found that TRAIL and CD95L activate JNK and p38 within 15 min. cFLIP variants and different caspase inhibitors blocked late death ligand induced JNK or p38 MAPK activation suggesting that these responses are secondary to cell death