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IL2 — PGP

Text-mined interactions from Literome

Mu et al., J Clin Immunol 1999 : Thus, human T cells do not markedly up-regulate their expression of functional Pgp molecules as detected by mAb 4E3 following activation, suggesting that Pgp does not play a major role in IL-2 secretion by activated T cells
Gollapudi et al., Genes Immun 2000 : These data show that P-gp is not required for secretion of IL-2 , IFN-gamma, IL-4, and IL-10 secretion in mice and IL-2 secretion in humans
Bonhomme-Faivre et al., Anticancer Drugs 2002 : Based on the premise that Taxol pharmacokinetic parameters could be modified as a result of diminished P-gp expression induced by recombinant interleukin ( rIL ) -2 and that this might elicit an interaction between the two drugs, we evaluated the pharmacokinetics of a novel strategy combining i.p. immunotherapy with rIL-2 and a cytotoxic agent, Taxol
Bonhomme-Faivre et al., Int J Pharm 2002 (Body Weight) : Inhibitors of P-glycoprotein (P-gp) ( verapamil ) or cytochrome P-450 ( ketoconazole ) may reduce IL2 production and T lymphocyte proliferation in vitro
Belliard et al., J Pharm Pharmacol 2002 : Caco-2 cells were used to investigate the effect of human recombinant interleukin-2 (IL2) on intestinal P-glycoprotein (P-gp) transporter activity in-vitro ... The inhibitory effect of IL2 on P-gp activity was found to be independent of tight junction function as demonstrated by constant transepithelial electrical resistance ( TEER ) measurements for all experimental conditions encountered in this study ( time and concentration of IL2 exposure )
Pawlik et al., J Pharm Pharmacol 2005 : P-gp inhibitors suppressed the release of IL-2 , IL-4, IFN-gamma and TNF-alpha from PHA stimulated MNC, whereas release of IL-6 and IL-10 remained unaffected