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IRS2 — RET
Pathways - manually collected, often from reviews:
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NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
IRS2 (IRS2)
→
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
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NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
IRS2 (IRS2)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Hennige et al., Mol Cell Endocrinol 2000
(Cell Transformation, Neoplastic...) :
Studying intracellular signaling pathways, which may be involved in malignant transformation of Ret-9bp expressing NIH3T3 cells, we could demonstrate
Ret-9bp dependent phosphorylation of
insulin receptor substrate-2 (IRS-2) with consecutive activation of phosphatidylinositol 3-kinase ( PI 3-kinase ) and protein kinase B ( PKB/AKT )
Miyagi et al., Mol Carcinog 2004
(Cell Transformation, Neoplastic...) :
Chronic expression of
RET/PTC 3 enhances basal and insulin stimulated PI3 kinase/AKT signaling and
increases IRS-2 expression in FRTL-5 thyroid cells