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CD8B — IL4

Text-mined interactions from Literome

El-Sheikh et al., J Autoimmun 1999 (Diabetes Mellitus, Type 1) : Depletion of either CD4 ( + ) or CD8 ( + ) T cells may prevent beta-cell destruction by decreasing IFN-gamma and IL-10 production in islets and increasing IL-4 and TNF-alpha production systemically
Lamousé-Smith et al., J Immunol 1999 : In this study, we have investigated in detail the cytokine requirements for the generation of allospecific CD8+ CTL in vitro and have found that IL-4 can augment the generation of anti-CD8-sensitive but not anti-CD8-resistant CTL, whereas IL-2 or IL-12 can augment the generation of both anti-CD8-sensitive and anti-CD8-resistant CTL
Tscharke et al., Arch Virol 1999 (Disease Models, Animal...) : The determine which cytokines might be involved in the CD8 ( + ) cell dependent response to ganglionic HSV infection, IL-2, IL-4 , IL-6, IL-10, and IFN-gamma mRNA levels were measured in infected ganglia from immunocompetent and anti-CD8 treated mice
Bot et al., Virology 2000 (Orthomyxoviridae Infections) : Our observations demonstrate a negative regulatory effect of IL-4 on memory Tc1/CD8 ( + ) T cells, but are also consistent with complementary mechanisms important for virus clearance such as virus neutralizing antibodies
Perambakam et al., Cancer Immunol Immunother 2002 (Prostatic Neoplasms) : Magnetic immuno-selection studies of one of the T-cell lines demonstrated that both cytolytic and interleukin-4 (IL-4) responses were mediated by CD8 ( + ), but not by CD4 ( + ) T cells
Rodrigues et al., J Interferon Cytokine Res 2002 : In contrast, absence of IL-4 did not affect total serum antibody response, T cell proliferative responses, or activation of IFN-gamma producing CD8 ( + ) T cells
Longhi et al., J Immunol 2006 (Hepatitis, Autoimmune) : In contrast, in patients, Tregs/CD8 ( + ) T cell cocultures lead to a higher increase of IL-4 secretion
Willemsen et al., J Immunol 2006 (Melanoma) : The introduction of a mutated cysteine motif in CD8alpha, which prevents its binding to LCK and linker for activation of T cells, did not adversely affect expression and T cell cytotoxicity, but counteracted the CD8alpha mediated down-regulation of IL-4 and IL-5, but not IL-10
Chaput et al., Gut 2009 (Adenocarcinoma...) : Finally, interleukin 6 and TGF beta 1 synergistically induced the generation of CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Morris et al., J Immunol 2009 : IL-4 effects are IL-7- and IL-15 independent, but MHC class I-dependent stimulation appears to be required for the mitogenic effect of IL-4 on naive phenotype CD8 ( + ) T cells
Brod et al., Cell Immunol 1990 : As class I MHC is the ligand for the CD8 molecule, expression of CD8 induced by IL-4 on CD4+ T cells may allow for increased nonspecific cell to cell contact during the course of an inflammatory response
Ma et al., Scand J Immunol 2011 (Colonic Neoplasms) : This study aims to investigate the role of tumour derived Foxhead box P3 (Foxp3) ( + ) interleukin (IL)-17 ( + ) T cells on suppressing tumour-specific CD8 ( + ) T cells
Nelson et al., J Reprod Immunol 2011 (Herpes Genitalis) : To address this, CD8 ( + ) T cells from normal OT-I mice or OT-I mice deficient in IFN? ( IFN? ( -/- ) ) or the IFN? receptor ( IFN?R ( -/- ) ) were activated in vitro in the presence of IFN? or IL-4 to generate a series of effector populations ( Tc1 and Tc2-like respectively ) that secreted different levels of IFN? and expressed different levels of HSV-specific cytolytic function
Sharma et al., J Immunol 2012 : Generation of TCF1 and ß-catenin dependent memory-like CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R
Olver et al., Immunology 2013 (Neoplasms, Experimental) : Interleukin-4 induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo
Horohov et al., J Immunol 1988 : When added at the onset of the culture, IL-4 augmented both cluster of differentiation (CD)8+ lymphoproliferation and MHC restricted, influenza virus-specific cytotoxicity
Paliard et al., Nature 1988 : CD8 induced by IL-4 can be functional as a monoclonal antibody to CD8 inhibited anti-CD3 mediated cytotoxicity by a double positive T-cell clone
de Waal Malefyt et al., Int Immunol 1995 : Differential regulation of IL-13 and IL-4 production by human CD8+ and CD4+ Th0, Th1 and Th2 T cell clones and EBV transformed B cells
Höllsberg et al., Proc Natl Acad Sci U S A 1995 : CD8 T-cell stimulation with the wild-type peptide antigen led to activation of p56lck kinase activity, interleukin 2 secretion, cytotoxicity, and clonal expansion
Wood et al., Clin Exp Immunol 1995 : IL-4 inhibited the generation of CD4, but not CD8 , CTL by normal cells and anti-IL-4 antibody was shown to increase the generation of CD4 CTL against B6 in F1 stimulated cultures
Su et al., J Immunol 1998 (Lymphocytic Choriomeningitis) : CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections : requirements for IL-2
Dieli et al., Int Immunol 1998 : The spontaneous release of IL-4 at day 1 was due to the alphabeta+ double negative ( CD4- CD8- ) T lymphocytes that also expressed NK1.1 and showed V ( alpha ) 14 rearrangement, while alphabeta+ CD4+ T lymphocytes were the source of the antigen-specific IL-4 production at day 4