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IL4 — TNFSF11

Text-mined interactions from Literome

Tunyogi-Csapo et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid...) : IL-4 suppressed RANKL expression and increased OPG expression, IFNgamma reduced the production of both RANKL and OPG, and IL-17 had only a modest effect on the expression of RANKL or OPG
Yu et al., J Immunol 2011 : Several groups have proposed that IL-4 inhibition of osteoclastogenesis is mediated by suppressing the RANKL induced activation of NF-?B
Fujii et al., Bone 2012 : IL-4 also inhibited TNF-a induced RANKL expression in the presence of TNF-a-responsive stromal cells in vivo ... In summary, we conclude that IL-4 inhibited TNF-a mediated osteoclast formation by inhibiting expression of RANKL in TNF-a activated stromal cells, and directly inhibited TNF-a activated osteoclast precursors in vivo via a T cell independent mechanism
Zheng et al., Biochem Pharmacol 2013 (Bone Resorption) : Coumermycin A1 also abrogated RANKL induced expression of interleukin-1ß , tumor necrosis factor-a, and inducible nitric oxide synthase in mouse BMMs. Consistent with the in vitro anti-osteoclastogenic effect, the aminocoumarin suppressed lipopolysaccharide induced osteoclast formation and bone loss in in vivo mouse experiments