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APP — TP53

Text-mined interactions from Literome

Xu et al., Proc Natl Acad Sci U S A 1999 (Alzheimer Disease...) : Wild-type APP also strongly inhibited p53 DNA binding activity and p53 mediated gene transactivation, whereas FAD-mutant APP did not
Ozaki et al., Biochem Biophys Res Commun 2006 : p53 was induced to be accumulated and associated with APP in response to cisplatin
Cuesta et al., Biochem J 2009 (Neuroblastoma) : The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP) ... In this study, we present evidence that p53 regulates the expression of the APP gene in neuroblastoma cells ... Transient transfection studies using plasmids that contain progressive deletions of the 5 ' region of the gene demonstrate that p53 represses APP promoter activity through a mechanism that is mediated by DNA sequences located downstream of the transcription start site ( +55/+101 ) ... Accordingly, expression of a dominant negative p53 mutant significantly increases the transcriptional activity of the APP promoter
Cuesta et al., FEBS Lett 2009 (Alzheimer Disease...) : We have recently reported that the tumor suppressor p53 inhibits APP gene transcription through the same DNA sequences that mediate an inhibitory effect of thyroid hormones