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EGFR — WNT4

Text-mined interactions from Literome

Schlange et al., Breast Cancer Res 2007 (Breast Neoplasms) : The effects of WNT signaling are mediated partly by EGFR transactivation in human breast cancer cells in a metalloprotease- and Src dependent manner
Hu et al., Molecular cancer 2010 (Neoplasms) : Wnt ligands can activate EGFR signaling through their 7-transmembrane domain receptor Frizzled while EGFR can activate ß-catenin via receptor tyrosine kinase-PI3K/Akt pathway ; EGFR has been shown to form a complex with ß-catenin and increase the invasion and metastasis of cancer cells