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SRY — WNT4

Text-mined interactions from Literome

Barrionuevo et al., Biol Reprod 2006 (Disorders of Sex Development) : Sry expression in mutant XY gonads indicates that downregulation of Wnt4 and Foxl2 is dependent on Sox9 rather than on Sry
Ito et al., J Reprod Dev 2006 : Silencing of Sry in the transformed cell lines using ribozymes or short hairpin RNAs ( shRNAs ) resulted in elevated levels of Wt1 and Wnt4 expression
Kim et al., PLoS Biol 2006 : In the mouse XY gonad, Sry normally initiates a feed-forward loop between Sox9 and Fgf9, which up-regulates Fgf9 and represses Wnt4 to establish the testis pathway
Bernard et al., Int J Biochem Cell Biol 2008 (Disorders of Sex Development) : We hypothesize that SRY prevents Wnt/beta-catenin signaling, thereby inhibiting ovarian development ... In HEK293T cells, SRY repressed beta-catenin mediated TCF dependent gene activation in the presence of a specific GSK3beta inhibitor or an activated beta-catenin mutant, suggesting that SRY inhibits Wnt signaling at the level of beta-catenin ... We conclude that SRY inhibits beta-catenin mediated Wnt signaling by a novel nuclear function of SRY that could be important in sex determination
Tamashiro et al., Biochim Biophys Acta 2008 : To seek a possible interaction between male and female sex determination mechanisms, we examined whether Sry affects Wnt/beta-catenin signaling ... Using the TOPFLASH reporter system to measure Lef/Tcf dependent transcriptional activity, we showed that ectopic expression of mouse Sry strongly suppressed Wnt/beta-catenin signaling in mouse embryonal carcinoma and human embryonic kidney cell lines
Lau et al., J Genet Genomics 2009 : Early studies showed that SRY represses such Wnt signaling, but also generated discrepancies on whether only mouse Sry is capable of inhibiting such Wnt signaling and whether both human and mouse SRY proteins are able to interact with beta-catenin, the intracellular messenger responsible for executing the Wnt signals