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MECOM — RUNX1

Text-mined interactions from Literome

Kumano et al., J Cell Physiol 2010 : During embryogenesis, both Runx1 and Evi-1 are essential for HSCs whereas in the adult, Runx1 and Evi-1 regulate HSCs negatively and positively, respectively
Maicas et al., Oncogene 2013 (Leukemia, Myeloid, Acute) : Moreover, we identified one of the roles of RUNX1 in the activation of EVI1 during megakaryocytic differentiation ... In conclusion, we define the minimal promoter region of EVI1 and demonstrate that RUNX1 and ELK1, two proteins with essential functions in hematopoiesis, regulate EVI1 in AML ... Furthermore, our results show that one of the mechanisms by which RUNX1 regulates the transcription of EVI1 is by acetylation of the histone H3 on its promoter region