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BMX — PI3
Text-mined interactions from Literome
Ekman et al., Oncogene 2000
:
Activation of
Bmx required
phosphatidylinositol 3-kinase (PI-3K) as demonstrated by the ability of PI-3K inhibitors to block the activation signal
Jiang et al., J Biol Chem 2007
(Prostatic Neoplasms) :
We found that the nonreceptor Tec family tyrosine kinase
Bmx/Etk was
activated by tyrosine phosphorylation downstream of Src and
PI 3-kinase in PTEN-deficient LNCaP and PC3 PCa cells and that Bmx down-regulation by short interfering RNA markedly inhibited LNCaP cell growth ... Bmx stimulation in response to heregulin-beta1 and EGF was Src dependent, and heregulin-beta1 stimulation of
Bmx was also
PI 3-kinase dependent