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MYLIP — TIMP3
Text-mined interactions from Literome
Gabriely et al., Mol Cell Biol 2008
(Disease Progression...) :
Specific inhibition of
miR-21 with antisense oligonucleotides
leads to elevated levels of RECK and
TIMP3 and therefore reduces MMP activities in vitro and in a human model of gliomas in nude mice
Selaru et al., Hepatology 2009
(Bile Duct Neoplasms...) :
Inhibitors of
miR-21 increased protein levels of programmed cell death 4 (PDCD4) and
tissue inhibitor of metalloproteinases 3 ( TIMP3 )
Liu et al., J Cell Sci 2010
:
In addition, downregulation of
TIMP3 is
mediated by the myogenesis promoting microRNA
miR-206
Limana et al., PloS one 2011
(Heart Failure...) :
HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and
miR-206 mediated inhibition of
TIMP-3
Zhang et al., Urology 2011
(Carcinoma, Renal Cell...) :
The reduction of
miR-21 inhibited Fas ligand and
TIMP3 expression by targeting the binding site within the 3 ' untranslated region
Panda et al., J Clin Endocrinol Metab 2012
(Carcinoma, Endometrioid...) :
In Ishikawa cells, gain of function of miR-98 repressed PGRMC1 and CYP19A1, and
miR-181a repressed PGR, DDX3X, and
TIMP3 at mRNA and protein levels through direct interactions with their respective 3'-untranslated regions and CCNE1 through miR-181a induced DDX3X repression, with miR-98 reducing the rate of cell proliferation as compared with controls
Zhang et al., Journal of translational medicine 2012
(Brain Neoplasms...) :
The present data indicate that
miR-221 and miR-222 directly
regulate cell invasion by targeting
TIMP3 and act as prognostic factors for glioma patients
Wang et al., Dig Dis Sci 2013
(Carcinoma, Squamous Cell...) :
miR-21 may be
involved in the tumorgenesis of ESCC by targeting FASL,
TIMP3 and RECK
Li et al., International journal of surgical oncology 2013
(Breast Neoplasms...) :
Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to
miR-21 Regulation of
TIMP-3 in Translation