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Eugenin et al., Proc Natl Acad Sci U S A 2007
(HIV Infections) :
Blockade of LRP mediated tat uptake, NMDA receptor activation, or neuronal nitric oxide synthase significantly reduces ensuing neuronal apoptosis, suggesting that formation of this complex is an early step in tat toxicity
Zhang et al., Am J Pathol 2007
(Brain Ischemia...) :
In conclusion, our results demonstrate that after MCAO the interaction between tPA and LRP results in NF-kappaB activation in astrocytes and induction of inducible nitric-oxide synthase expression in the ischemic tissue, suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia