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FOXO3 — IKBKB

Pathways - manually collected, often from reviews:

• NCI Pathway Database FoxO family signaling: IKK beta (IKBKB) → FOXO3A (FOXO3) (modification, activates) Hu et al., Cell 2004*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IKBKB — FOXO3 Hu et al., Cell 2004*
• IRef Bind_translation Interaction: IKBKB — FOXO3 (affinity chromatography technology) Hu et al., Cell 2004*
• IRef Bind_translation Interaction: IKBKB — FOXO3 (coimmunoprecipitation) Hu et al., Cell 2004*
• IRef Bind_translation Interaction: IKBKB — FOXO3 (experimental interaction detection) Hu et al., Cell 2004*
• IRef Biogrid Interaction: FOXO3 — IKBKB (direct interaction, pull down) Hu et al., Cell 2004*
• IRef Biogrid Interaction: FOXO3 — IKBKB (physical association, affinity chromatography technology) Hu et al., Cell 2004*
• IRef Hprd Interaction: IKBKB — FOXO3 (in vitro) Hu et al., Cell 2004*
• IRef Hprd Interaction: IKBKB — FOXO3 (in vivo) Hu et al., Cell 2004*
• IRef Innatedb Interaction: IKBKB — FOXO3 (unknown, -) Luron et al., Eur J Immunol 2012*
• IRef Ophid Interaction: IKBKB — FOXO3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Hu et al., Cell 2004 (Breast Neoplasms...) : We provide evidence for such a mechanism by showing that IkappaB kinase (IKK) physically interacts with, phosphorylates, and inhibits FOXO3a independent of Akt and causes proteolysis of FOXO3a via the Ub-dependent proteasome pathway
Lesniewski et al., J Gerontol A Biol Sci Med Sci 2011 : We hypothesized that I kappa B kinase (IKK) mediated nuclear factor kappa B and forkhead BoxO3a phosphorylation will be associated with age related endothelial dysfunction