◀ Back to MAPK3

MAPK3 — TLR2

Text-mined interactions from Literome

Jiang et al., J Biol Chem 2003 (MAP Kinase Signaling System) : However, we find that, in response to dsRNA, TLR3 can mediate the activation of both NFkappaB and mitogen activated protein ( MAP ) kinases in IL-1-unresponsive mutant cell lines, including IRAK-deficient I1A and I3A cells, which are defective in a component that is downstream of IL-1R but upstream of IRAK
Parker et al., J Immunol 2004 (MAP Kinase Signaling System) : TLR2 activation caused slower induction of the NF-kappa B and mitogen activated protein kinase signaling pathways and yet a much enhanced and prolonged macrophage-inflammatory protein 1 alpha ( CC chemokine ligand 3 ) protein production, when compared with TLR4 stimulation
Asehnoune et al., Cell Signal 2005 : Activation of p38, JNK, and ERK 1/2 in response to TLR2 engagement was diminished in neutrophils in which PKCalpha/beta was inhibited
Into et al., Cell Microbiol 2005 : Thus, MLP and PGN have capabilities to induce ASK1 dependent signalling pathways which regulate p38 MAPK activation through TLR2 , leading to activation of NF-kappaB and AP-1 as well as induction of cell death
Hung et al., Nephrol Dial Transplant 2006 : These findings demonstrate that activation of p38 MAPK and release of chemokines by LMPS are mediated by TLR2 in renal proximal tubule cells
Salojin et al., J Immunol 2006 (Arthritis, Experimental...) : MKP-1-deficient macrophages also show enhanced constitutive and TLR induced activation of p38 MAPK
Didierlaurent et al., Mol Cell Biol 2006 : Activation of interleukin-1 (IL-1) receptor ( IL-1R ), Toll-like receptor 2 (TLR2) , and TLR4 triggers NF-kappaB and mitogen activated protein kinase ( MAPK ) -dependent signaling, thereby initiating immune responses
Chi et al., Proc Natl Acad Sci U S A 2006 (Shock, Septic) : Thus, p38 MAPK plays a critical role in mediating IL-10 synthesis in TLR signaling
Pennini et al., J Immunol 2006 (MAP Kinase Signaling System) : Thus, CIITA expression was inhibited by TLR2 induced MAPK signaling that caused histone hypoacetylation at CIITA pIV and suppression of CIITA transcription
Yadav et al., Blood 2006 : We determined that mitogen activated protein kinase ( MAPK ) activation and tumor necrosis factor-alpha (TNF-alpha) production in macrophage infected with Mycobacterium avium or M smegmatis is dependent on myeloid differentiation factor 88 ( MyD88 ) and TLR2 but not TLR4, MR, or CR3
Moeinpour et al., Mol Immunol 2007 (Hemorrhage...) : Inflammatory mediators, Toll-like receptor ( TLR ) and myeloid differentiation adaptor protein ( MyD88 ) expression, and the activation of mitogen activated protein kinase ( MAPK ) were determined
Banerjee et al., Immunol Cell Biol 2007 : Toll-like receptor ( TLR ) signaling leads to the activation of mitogen activated protein kinase and nuclear factor-kappaB signaling pathways
Elass et al., FEBS Lett 2008 : These findings suggest that the binding of LM to TLR2 triggers MAPK activation, followed by an up-regulation of MKP-1 expression, which in turn may act as a negative regulator of MAPK activation
Watarai et al., Proc Natl Acad Sci U S A 2008 : However, when coupled with Sema6D, a ligand for Plexin-A1, limited TLR-stimulation resulted in PDC-TREM mediated DAP12 dependent phosphorylation of phosphoinositide 3-kinase (PI3K) and extracellular regulated kinase (Erk) 1/2 at 6-9 h, and IFN-alpha was produced
MacLeod et al., Clinical and vaccine immunology : CVI 2008 : Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin
Lee et al., J Clin Immunol 2009 : Toll-like receptor (TLR) 2 was required for ROS generation, chemokine production, and MAPK activation following stimulation with the 30-kDa Ag
Shibata et al., J Invest Dermatol 2009 (Dermatitis...) : By using several inhibitors and activators, we found that TLR2 gene induction by glucocorticoids was mediated by the suppression of p38 MAPK activity following induction of MAPK phosphatase-1
Chandra et al., Clin Exp Immunol 2008 (Leishmaniasis, Visceral...) : Parasites also modulated the TLR2 stimulated mitogen activated protein kinase ( MAPK ) pathway by suppressing MAPK P(38) phosphorylation and activating extracellular regulated kinase (ERK)1/2 phosphorylation
Caricilli et al., J Endocrinol 2008 (Insulin Resistance) : In addition, data show that the inhibition of TLR2 expression prevents the activation of IKBKB, MAPK8 , and serine phosphorylation of IRS1 in DIO mice, suggesting that TLR2 is a key modulator of the crosstalk between inflammatory and metabolic pathways
Park et al., J Immunol 2009 : Protein kinase D1 (PKD1) has been shown to be involved in certain MAPK activation and cytokine expression by several TLR ligands
Thaikoottathil et al., Mol Immunol 2011 : MAPK/AP-1 activation mediates TLR2 agonist induced SPLUNC1 expression in human lung epithelial cells ... In the present study, we investigated if TLR2 induced mitogen activated protein kinase ( MAPK ) /activator protein-1 (AP-1) signaling regulates SPLUNC1 expression in human lung epithelial cells ... Our results for the first time demonstrate that TLR2 mediated MAPK/AP-1 activation up-regulates lung epithelial SPLUNC1 expression at the transcriptional level
Yang et al., Infect Immun 2011 (Plague) : Analysis of this network showed that signaling pathways important for host immune responses were preferentially targeted by Y. pestis, including the pathways involved in focal adhesion, regulation of cytoskeleton, leukocyte transendoepithelial migration, and Toll-like receptor ( TLR ) and mitogen activated protein kinase ( MAPK ) signaling
Song et al., Toxicol Pathol 2012 : The regulatory effect of complement on TLR signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and involved increased mitogen activated protein kinase and nuclear factor ?B activation
Zbinden-Foncea et al., Med Sci Sports Exerc 2012 (MAP Kinase Signaling System) : TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle
Boyd et al., Exp Gerontol 2012 (Disease Susceptibility...) : Following infection of isolated AMs with live Spn, a significant age related decline in TLR2 induced phosphorylation of p65 NF?B, JNK and p38 MAPK , and an increase in ERK phosphorylation was observed by immunoblotting
Zhang et al., Cell Mol Immunol 2012 : In addition, HKBA exposure triggered the TLR2 mediated activation of both p38 and extracellular signal regulated kinase 1/2 ( ERK1/2 )
Lee et al., Arterioscler Thromb Vasc Biol 2012 (Atherosclerosis) : Our results suggest that on ligand binding, TLR2 activates p38 mitogen associated protein kinase and extracellular signal regulated kinase 1/2 signaling in VSMCs ... Our results suggest that on ligand binding, TLR2 activates p38 mitogen associated protein kinase and extracellular signal regulated kinase 1/2 signaling in VSMCs
Beaudoin et al., Biochem Biophys Res Commun 2012 (Cystic Fibrosis) : Inactivation of mucA ( the gene responsible for the mucoid phenotype ) in PAO1 leads to p38a MAPK activation by both TLR2 and TLR5, as observed in the clinical mucoid isolate PACF508
Chang et al., Cell Death Differ 2013 (Carcinoma, Hepatocellular) : Furthermore, TLR2 signal induces sustained phosphorylation of extracellular signal regulated kinase 1/2 to facilitate this autophagy dependent NF-?B regulation
Yee et al., Eur J Immunol 2013 : ß2 integrins inhibit TLR responses by regulating NF-?B pathway and p38 MAPK activation
de Almeida et al., Infect Immun 2013 (Brucellosis...) : Furthermore, our findings demonstrated that the mitogen activated protein kinase ( MAPK ) signaling pathway is impaired in TLR2, TLR6 , and TLR2/6 knockout ( KO ) DCs when infected with B. abortus, which may account for the lower proinflammatory cytokine production observed in TLR6 KO mouse dendritic cells ... Furthermore, our findings demonstrated that the mitogen activated protein kinase ( MAPK ) signaling pathway is impaired in TLR2 , TLR6, and TLR2/6 knockout ( KO ) DCs when infected with B. abortus, which may account for the lower proinflammatory cytokine production observed in TLR6 KO mouse dendritic cells
Dimitrakopoulos et al., Microbes Infect 2013 : B. melitensis caused a delayed, TLR2 dependent MAPK activation
Wagner et al., Arterioscler Thromb Vasc Biol 2013 (Ischemia...) : The effects of anti-TLR2 ABs were similar to those exerted by stromal cell derived factor-1, and we show that anti-TLR2 ABs yet not TLR2 ligands lead to comparable activation of extracellular signal regulated kinase1/2 and AKT but not p38 mitogen activated protein kinase as activation of the CXCR4 canonical signal transduction pathways by stromal cell derived factor-1