◀ Back to LEP
LEP — STAT5A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Maccarrone et al., J Biol Chem 2003
:
Leptin binding to the receptor
triggered activation of STAT3 but not STAT1 or
STAT5 or the mitogen activated protein kinases p38, p42, and p44
Mütze et al., Neurosci Lett 2007
(Body Weight) :
In particular, the entire arcuate nucleus (ARC), the ventral premammilary nucleus ( PMV ), and the supraoptic nucleus ( SO ) showed an enhanced nuclear
STAT5 translocation in
response to
leptin when compared to saline, 120 min after the respective injection ... The functional relevance of
leptin induced nuclear
STAT5 activation in hypothalamic cells still has to be determined
Gong et al., J Biol Chem 2007
(MAP Kinase Signaling System) :
Thus, these data demonstrate the phosphorylation of Tyr ( 1077 ) on LepRb during receptor activation, substantiate the hypothalamic
regulation of
STAT5 and S6 by
leptin , and define the alternate LepRb signaling pathways that mediate each of these signals and their effects in cultured cells
Morton et al., J Biol Chem 1998
(Obesity) :
Leptin mediated induction of a number of immediate-early genes and
activation of STAT3 and
STAT5 in a human model of small intestine epithelium, CACO-2 cells, corroborate this effect