Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
GAB1
→
INSR
(directlyIncreases, GAB1 Activity)
Evidence: Phosphotyrosine at site 960 of the b subunit just inside the membrane creates an NPXpY-recognition motif for the PTB domain of the IRS proteins. Modification of this tyrosine completely inhibits subsequent phosphorylation of IRS-1 and other insulin receptor substrates and leads to loss of most insulin-dependent biological actions
OpenBEL Selventa BEL large corpus:
GAB1
→
INSR
(directlyIncreases, GAB1 Activity)
Evidence: Insulin receptor substrates are a growing family of proteins that are phosphorylated by the activated insulin receptor. To date, nine members of this family have been identified, including IRS-1 (17, 18), IRS-2 (19), IRS-3 (20), and IRS-4 (21), which are generally viewed as the most specific for insulin signaling; Gab-1 (22); Shc, which has three isoforms (23); and p62dok Following insulin binding, the receptor undergoes autophosphorylation on multiple tyrosine residues. This results in activati...
OpenBEL Selventa BEL large corpus:
GAB1
→
INSR
(directlyIncreases, GAB1 Activity)
Evidence: insulin stimulates the mitogen-activated protein (MAP) kinase extracellular signalregulated kinase (ERK) (Fig. 2). This pathway involves the tyrosine phosphorylation of IRS proteins and/or Shc, which in turn interact with the adapter protein Grb2, recruiting the Son-of-sevenless (SOS) exchange protein to the plasma membrane for activation of Ras.
OpenBEL Selventa BEL large corpus:
GAB1
→
INSR
(directlyIncreases, GAB1 Activity)
Evidence: The insulin receptor is a tyrosine kinase that catalyzes the phosphorylation of several intracellular substrates, including the insulin receptor substrate (IRS) proteins [2], GAB-1 [3], Shc [4], APS [5], p60DOK [6], SIRPS [7] and c-Cbl
OpenBEL Selventa BEL large corpus:
GAB1
→
INSR
(directlyIncreases, GAB1 Activity)
Evidence: insulin receptor is a tyrosine kinase that catalyzes the phosphorylation of several intracellular substrates, including the insulin receptor substrate (IRS) proteins, GAB-1, Shc, APS, p60(DOK), SIRPS, and c-Cbl
OpenBEL Selventa BEL large corpus:
GAB1
→
INSR
(directlyIncreases, GAB1 Activity)
Evidence: Gab-1 is heavily phosphorylated by the epidermal growth factor receptor, but poorly by the insulin receptor
OpenBEL Selventa BEL large corpus:
GAB1
→
INSR
(directlyIncreases, GAB1 Activity)
Lehr et al., Biochemistry 2000* Evidence: Our results demonstrate that hGab-1 was phosphorylated by IR at eight tyrosine residues (Y242, Y285, Y373, Y447, Y472, Y619, Y657, and Y689). Seventy-five percent of the identified radioactivity was incorporated into tyrosine residues Y447, Y472, and Y619 exhibiting features (NYVPM motif) of potential binding sites for the regulatory subunit (p85) of phosphatidylinositol (PI)-3 kinase.