Gene interactions and pathways from curated databases and text-mining

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JAK3 — LRPPRC

Pathways - manually collected, often from reviews:

  • BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) → STAT3 (modification, activates)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → STAT3 (modification, activates)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → JAKs (JAK2/JAK1/JAK3) (modification, collaborate)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  • BioCarta il 6 signaling pathway: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  • BioCarta role of erbb2 in signal transduction and oncology: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  • BioCarta role of erbb2 in signal transduction and oncology: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) (modification, collaborate)
  • BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) (modification, collaborate)
  • BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)

Text-mined interactions from Literome

Matsuda et al., J Biol Chem 1995 : We previously showed that gp130 stimulation rapidly activates Jak , Btk, and Tec tyrosine kinases, all of which constitutively associate with gp130
Kunisada et al., Circulation 1996 : Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes