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MMP2 — NGF

Text-mined interactions from Literome

Okada et al., Clin Exp Metastasis 2004 (MAP Kinase Signaling System...) : In the present study we investigated the effect of NGF on the expression and activity of MMP-2 in human pancreatic cancer cells ... The NGF induced increase in MMP-2 expression and activity lead to an enhanced invasion in vitro
Park et al., J Biol Chem 2007 : NGF stimulated matrix metalloproteinase (MMP)-2 mRNA expression and protein secretion in human umbilical vein endothelial cells ... We demonstrated that NGF induced MMP-2 secretion, invasion, and cord formation are regulated via activation of the NGF receptor, TrkA, phosphatidylinositol 3-kinase (PI3K), and Akt using various pharmacological inhibitors ... Introduction of NGF neutralizing antibodies, dominant negative Akt, or wild-type PTEN effectively inhibited NGF induced MMP-2 secretion and cord formation ... Deletion and site directed mutagenesis analysis of the MMP-2 promoter demonstrated that the AP-2 binding site is critical for NGF induced MMP-2 promoter activity ... Furthermore, transfection of AP-2 small interfering RNA effectively blocked NGF induced MMP-2 secretion and cord formation
Dagnell et al., Translational research : the journal of laboratory and clinical medicine 2007 : Therefore, we studied the effect of NGF , BDNF, and NT-3 on human bronchial smooth muscle cell ( HBSMC ) migration and MMP-2 and MMP-9 secretion ... BDNF, NT-3, and NGF increased MMP-9, but not MMP-2 , secretion as shown by zymography
Muir et al., Exp Cell Res 1994 : Also, NGF increased the expression and activation of 72-kDa type IV collagenase , suggesting a role for this matrix degrading metalloproteinase in neuronal regeneration