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CREB1 — PGC
Text-mined interactions from Literome
Herzig et al., Nature 2001
(Diabetes Mellitus, Experimental...) :
Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the
activation of
PGC-1 by
CREB in liver contributes importantly to the pathogenesis of this disease
Herzig et al., Nature 2003
(Fatty Liver) :
The coordinate
induction of
PGC-1 and repression of PPAR-gamma by
CREB during fasting provides a molecular rationale for the antagonism between insulin and counter-regulatory hormones, and indicates a potential role for CREB antagonists as therapeutic agents in enhancing insulin sensitivity in the liver
Mehta et al., Int J Biochem Cell Biol 2013
:
Similarly,
CREB inhibition
reduced CREB activation and
PGC-1a protein levels in selenoprotein H transfected cells
Zuo et al., Biochem Biophys Res Commun 2013
(Intermittent Claudication) :
Moreover, the increased expression of
PGC-1a induced by cilostazol could be
inhibited by downregulation of
CREB using CREB siRNA at both mRNA and protein levels