te Welscher et al., Genes Dev 2002
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The bHLH transcription factor dHAND is required for establishment of SHH signaling by the limb bud organizer in posterior mesenchyme, a step crucial to development of vertebrate paired appendages
Thewissen et al., Proc Natl Acad Sci U S A 2006
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We find that failure to establish a ZPA is associated with the absence of Hand2 , an upstream regulator of Shh Galli et al., PLoS Genet 2010
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Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development
Zhang et al., Development 2010
(Polydactyly) :
Previous studies have shown that TWIST1 functions by forming homodimers or heterodimers with other bHLH factors including HAND2 , a key positive regulator of Shh expression